Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 2/20 | 0.32 |
| ▸ | MMP14 | P50281 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.31 |
| ▸ | NCF1 | P14598 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12210252 | 0.90 | KDM4E (0.35) | SCN9AKDM4EHSD17B10SMN1; SMN2LMNA | |
| SCHEMBL15060795 | 0.88 | MTNR1A (0.34) | SCN9AKDM4EHSD17B10SMN1; SMN2LMNA | |
| SCHEMBL13273917 | 0.85 | PPARG (0.41) | KDM4EHSD17B10SMN1; SMN2LMNARAB9A | |
| SCHEMBL18404401 | 0.79 | LMNA (0.41) | KDM4EHSD17B10SMN1; SMN2LMNARAB9A | |
| SCHEMBL15060784 | 0.78 | PDE5A (0.37) | KDM4EHSD17B10SMN1; SMN2MEN1TSHR | |
| SCHEMBL12210145 | 0.77 | MCHR1 (0.45) | KDM4ESMN1; SMN2LMNARAB9AMEN1 | |
| SCHEMBL12210495 | 0.77 | KDM4E (0.38) | KDM4EHSD17B10SMN1; SMN2KMT2APDE5A | |
| SCHEMBL13273928 | 0.76 | HSP90AA1 (0.37) | KDM4EHSD17B10SMN1; SMN2LMNAPDE5A | |
| SCHEMBL12212023 | 0.75 | ACSS2 (0.47) | KDM4EHSD17B10SMN1; SMN2LMNARAB9A | |
| SCHEMBL15061690 | 0.74 | PDE5A (0.35) | KDM4EHSD17B10MEN1KMT2APDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2380881-B1 | NOVEL BICYCLIC HETEROCYCLIC COMPOUND | SUMITOMO DAINIPPON PHARMA CO LTD (JP) | 2017-01-25 | — | — | EP | disclosed |