Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29223070 | 0.83 | EPHX1 (0.46) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL5959811 | 0.81 | EPHX1 (0.44) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL282155 | 0.81 | EPHX1 (0.44) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL1840802 | 0.81 | EPHX1 (0.44) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL9565518 | 0.81 | ACHE (0.44) | EPHX1ACHESMN1; SMN2NPC1RAB9A | |
| SCHEMBL29222977 | 0.80 | EPHX1 (0.51) | EPHX1ACHE | |
| SCHEMBL7404539 | 0.80 | ACHE (0.46) | EPHX1ACHEALDH1A1 | |
| SCHEMBL6033535 | 0.79 | EPHX1 (0.48) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4592660 | 0.79 | EPHX1 (0.42) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL8303799 | 0.79 | EPHX1 (0.42) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784628-A1 | INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | Vertex Pharmaceuticals Incorporated (US) | 1997-07-23 | — | — | EP | disclosed |
| WO-1995035308-A1 | INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1995-12-28 | — | — | WO | disclosed |