Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 2/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19012592 | 0.89 | GPR119 (0.37) | CYP2C19ALDH1A1SMN1; SMN2GPR119CTSB | |
| SCHEMBL19012741 | 0.88 | ACACB (0.41) | USP2ALDH1A1MAPK1CTSBCTSK | |
| SCHEMBL18436935 | 0.86 | SMN1; SMN2 (0.47) | USP2CYP2C19ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL19012736 | 0.85 | MAPT (0.39) | ALDH1A1MAPK1SMN1; SMN2CHRM2ALOX12 | |
| SCHEMBL20034286 | 0.85 | LMNA (0.37) | ALDH1A1MAPK1SMN1; SMN2HIF1ACYP2C9 | |
| SCHEMBL25154495 | 0.76 | SMN1; SMN2 (0.40) | USP2CYP2C19ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL25154435 | 0.76 | SMN1; SMN2 (0.40) | USP2CYP2C19ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL25154681 | 0.76 | SMN1; SMN2 (0.40) | USP2CYP2C19ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL25154672 | 0.76 | SMN1; SMN2 (0.40) | USP2CYP2C19ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL21336726 | 0.75 | GPR119 (0.56) | ALDH1A1GPR119NR1H2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |