Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 4/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.32 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | ACP1 | P24666 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.31 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.31 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21336795 | 0.87 | NTRK1 (0.33) | EGLN1MAPK14SLC22A12 | |
| SCHEMBL21336578 | 0.82 | TTK (0.32) | EGLN1PDCD1CD274SLC22A12 | |
| SCHEMBL21336708 | 0.81 | HTR1A (0.36) | EGLN1PDCD1CD274SLC22A12ACP1 | |
| SCHEMBL18436820 | 0.80 | ACP1 (0.36) | ACP1 | |
| SCHEMBL18436682 | 0.80 | RAD52 (0.38) | EGLN1SLC22A12ACP1 | |
| SCHEMBL18436867 | 0.79 | ENPP1 (0.34) | KDM4EMAPTSAE1UBA2 | |
| SCHEMBL18436729 | 0.79 | CD274 (0.43) | EGLN1PDCD1CD274KDM4E | |
| SCHEMBL18436930 | 0.78 | POLB (0.39) | EGLN1PDCD1CD274KDM4EMAPT | |
| SCHEMBL18436859 | 0.77 | TP53 (0.44) | MAPT | |
| SCHEMBL18436545 | 0.76 | MTNR1A (0.39) | EGLN1PDCD1CD274KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |