Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21336708 | 0.90 | HTR1A (0.36) | RAD52HRH4STAT3FYNEGLN1 | |
| SCHEMBL18436729 | 0.85 | CD274 (0.43) | EGLN1KDM4AKDM5B | |
| SCHEMBL18436820 | 0.84 | ACP1 (0.36) | RAD52HRH4IRAK4ACP1KDM4A | |
| SCHEMBL18436930 | 0.84 | POLB (0.39) | EGLN1HTR1AKDM4AKDM5B | |
| SCHEMBL18436944 | 0.83 | GRIA2 (0.40) | STAT3IRAK4EGLN1HTR1AADRA1D | |
| SCHEMBL18436758 | 0.82 | KDM1A (0.34) | KDM1AIRAK4HTR1AADRA1DADRA1A | |
| SCHEMBL18436545 | 0.81 | MTNR1A (0.39) | EGLN1KDM4AKDM5B | |
| SCHEMBL21336795 | 0.81 | NTRK1 (0.33) | STAT3KDM1AEGLN1HTR1AADRA1D | |
| SCHEMBL21336578 | 0.81 | TTK (0.32) | HRH4STAT3FYNKDM1AEGLN1 | |
| SCHEMBL18436763 | 0.80 | HRH4 (0.38) | HRH4KDM1AACP1KDM4AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-B1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2019-09-11 | — | — | EP | disclosed |
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |