Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | RBP4 | P02753 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18436805 | 0.89 | SMN1; SMN2 (0.50) | HSD11B1L3MBTL1SMN1; SMN2CHRNB2CHRNB4 | |
| SCHEMBL19012370 | 0.89 | SMN1; SMN2 (0.50) | HSD11B1L3MBTL1SMN1; SMN2CHRNB2CHRNB4 | |
| SCHEMBL18436815 | 0.85 | CSF1R (0.46) | HSD11B1L3MBTL1SMN1; SMN2CHRNB2CHRNB4 | |
| SCHEMBL19001092 | 0.85 | PLA2G1B (0.51) | HSD11B1L3MBTL1SMN1; SMN2CHRNB2CHRNB4 | |
| SCHEMBL19001032 | 0.85 | PLA2G1B (0.51) | HSD11B1L3MBTL1SMN1; SMN2CHRNB2CHRNB4 | |
| SCHEMBL19012742 | 0.85 | HSD11B1 (0.46) | HSD11B1L3MBTL1SMN1; SMN2CHRNB2CHRNB4 | |
| SCHEMBL19012534 | 0.85 | HSD11B1 (0.46) | HSD11B1L3MBTL1SMN1; SMN2CHRNB2CHRNB4 | |
| SCHEMBL21336587 | 0.77 | ALDH1A1 (0.46) | HSD11B1SMN1; SMN2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL20750442 | 0.74 | CHRNB2 (0.61) | HSD11B1L3MBTL1SMN1; SMN2CHRNB2CHRNB4 | |
| SCHEMBL20690378 | 0.69 | L3MBTL1 (0.67) | L3MBTL1SMN1; SMN2CHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |