Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 11/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18436930 | 0.87 | POLB (0.39) | EGLN1KDM4EKDM4AKDM5BCNR2 | |
| SCHEMBL18436729 | 0.87 | CD274 (0.43) | EGLN1KDM4EKDM4AKDM5BMAPK1 | |
| SCHEMBL18436919 | 0.83 | EGLN1 (0.36) | EGLN1KDM4AKDM5BCNR2IRAK4 | |
| SCHEMBL18436545 | 0.83 | MTNR1A (0.39) | EGLN1KDM4EKDM4AKDM5BCNR2 | |
| SCHEMBL18436737 | 0.83 | KDM4E (0.46) | EGLN1KDM4EMAPK1 | |
| SCHEMBL18436859 | 0.83 | TP53 (0.44) | MAPK1 | |
| SCHEMBL21336708 | 0.82 | HTR1A (0.36) | EGLN1KDM4AKDM5BPDCD1CD274 | |
| SCHEMBL18436944 | 0.81 | GRIA2 (0.40) | EGLN1KDM4AKDM5BIRAK4 | |
| SCHEMBL18436681 | 0.81 | GSK3B (0.38) | KDM4AKDM5BCNR2PDCD1CD274 | |
| SCHEMBL18436682 | 0.80 | RAD52 (0.38) | EGLN1KDM4AKDM5BIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |