Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 16/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 14/20 | 0.80 |
| ▸ | GAA | P10253 | 12/20 | 0.80 |
| ▸ | L3MBTL1 | Q9Y468 | 11/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 11/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.80 |
| ▸ | ALOX12 | P18054 | 9/20 | 0.80 |
| ▸ | ALOX15 | P16050 | 8/20 | 0.80 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.80 |
| ▸ | HTT | P42858 | 5/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | TSHR | P16473 | 3/20 | 0.70 |
| ▸ | MEN1 | O00255 | 7/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.63 |
| ▸ | APP | P05067 | 1/20 | 0.63 |
| ▸ | SNCA | P37840 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2475972 | 0.83 | GAA (0.63) | MAPTKDM4EGAAL3MBTL1MAPK1 | |
| SCHEMBL854818 | 0.82 | L3MBTL1 (0.64) | MAPTKDM4EGAAL3MBTL1MAPK1 | |
| SCHEMBL277165 | 0.80 | ALDH1A1 (0.54) | MAPTKDM4EGAAL3MBTL1MAPK1 | |
| SCHEMBL2464412 | 0.80 | GAA (0.67) | MAPTKDM4EGAAL3MBTL1MAPK1 | |
| SCHEMBL30854966 | 0.80 | L3MBTL1 (0.62) | MAPTKDM4EGAAL3MBTL1MAPK1 | |
| SCHEMBL18118180 | 0.79 | ALDH1A1 (0.57) | MAPTKDM4EGAAL3MBTL1MAPK1 | |
| SCHEMBL847809 | 0.79 | ALDH1A1 (0.57) | MAPTKDM4EGAAL3MBTL1MAPK1 | |
| SCHEMBL30438522 | 0.77 | KDM4E (0.68) | MAPTKDM4EGAAL3MBTL1MAPK1 | |
| SCHEMBL14680275 | 0.77 | MAPT (0.78) | MAPTKDM4EGAAL3MBTL1MAPK1 | |
| SCHEMBL18118174 | 0.77 | HPGD (0.52) | MAPTKDM4EGAAL3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318140-B9 | NOVEL AMIDE DERIVATIVES AND MEDICINAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2014-05-21 | — | — | EP | disclosed |
| US-8198454-B2 | Amide derivatives and medicinal use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-06-12 | — | — | US | disclosed |
| EP-1318140-B1 | NOVEL AMIDE DERIVATIVES AND MEDICINAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-05-18 | — | — | EP | disclosed |
| US-7855297-B2 | Amide derivatives and medicinal use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-12-21 | — | — | US | disclosed |
| US-20100041656-A1 | Novel amide derivatives and medicinal use thereof | NAKAMURA MITSUBARU | 2010-02-18 | — | — | US | disclosed |
| US-20040138223-A1 | Novel amide derivatives and medicinal use thereof ugs | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2004-07-15 | — | — | US | disclosed |
| EP-1318140-A1 | NOVEL AMIDE DERIVATIVES AND MEDICINAL USE THEREOF UGS | Mitsubishi Pharma Corporation (JP) | 2003-06-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041656-A1 | Novel amide derivatives and medicinal use thereof | C5AR1, C5AR2, C3AR1 | MAPT 728/4885KDM4E 4468/4885GAA 3289/4885 |
| US-20040138223-A1 | Novel amide derivatives and medicinal use thereof ugs | C5AR1, C5AR2, C1S | MAPT 700/4885KDM4E 4672/4885GAA 1702/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.