Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.74 |
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | KCNQ3 | O43525 | 5/20 | 0.60 |
| ▸ | KCNQ2 | O43526 | 5/20 | 0.60 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.60 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.60 |
| ▸ | BACE1 | P56817 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.56 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4169885 | 0.90 | RAB9A (0.68) | RAB9ASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL4167905 | 0.90 | RAB9A (0.68) | RAB9ASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL8361559 | 0.85 | RAB9A (1.00) | RAB9ASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL1986996 | 0.84 | KCNQ3 (0.82) | RAB9ASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL5215207 | 0.84 | KCNQ3 (0.81) | RAB9ASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL4619718 | 0.84 | RAB9A (0.60) | RAB9ASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL3313800 | 0.83 | RAB9A (0.75) | RAB9ASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL2302748 | 0.82 | RAB9A (0.74) | RAB9ASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL23844169 | 0.82 | LMNA (0.76) | RAB9ASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL2801974 | 0.82 | KCNQ3 (0.85) | RAB9ASMN1; SMN2MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318140-B9 | NOVEL AMIDE DERIVATIVES AND MEDICINAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2014-05-21 | — | — | EP | disclosed |
| US-8198454-B2 | Amide derivatives and medicinal use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-06-12 | — | — | US | disclosed |
| EP-1318140-B1 | NOVEL AMIDE DERIVATIVES AND MEDICINAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-05-18 | — | — | EP | disclosed |
| US-7855297-B2 | Amide derivatives and medicinal use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-12-21 | — | — | US | disclosed |
| US-20100041656-A1 | Novel amide derivatives and medicinal use thereof | NAKAMURA MITSUBARU | 2010-02-18 | — | — | US | disclosed |
| US-20040138223-A1 | Novel amide derivatives and medicinal use thereof ugs | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2004-07-15 | — | — | US | disclosed |
| EP-1318140-A1 | NOVEL AMIDE DERIVATIVES AND MEDICINAL USE THEREOF UGS | Mitsubishi Pharma Corporation (JP) | 2003-06-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041656-A1 | Novel amide derivatives and medicinal use thereof | C5AR1, C5AR2, C3AR1 | RAB9A 1166/4885SMN1; SMN2 1200/4885MAPT 728/4885 |
| US-20040138223-A1 | Novel amide derivatives and medicinal use thereof ugs | C5AR1, C5AR2, C1S | RAB9A 1330/4885SMN1; SMN2 1561/4885MAPT 700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.