Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.66 |
| ▸ | KCNQ3 | O43525 | 7/20 | 0.65 |
| ▸ | KCNQ2 | O43526 | 7/20 | 0.65 |
| ▸ | KCNE1 | P15382 | 5/20 | 0.65 |
| ▸ | KCNQ1 | P51787 | 5/20 | 0.65 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.64 |
| ▸ | BACE1 | P56817 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1986996 | 0.89 | KCNQ3 (0.82) | RAB9ASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL2306301 | 0.89 | RAB9A (0.76) | RAB9ASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL5215207 | 0.88 | KCNQ3 (0.81) | RAB9ASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL8361559 | 0.86 | RAB9A (1.00) | RAB9ASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL2801974 | 0.86 | KCNQ3 (0.85) | RAB9ASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL1844238 | 0.83 | RAB9A (0.74) | RAB9ASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL2302748 | 0.83 | RAB9A (0.74) | RAB9ASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL14516647 | 0.82 | RAB9A (0.72) | RAB9ASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL2302302 | 0.82 | RAB9A (0.72) | RAB9ASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL4177141 | 0.82 | RAB9A (0.68) | RAB9ASMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324385-B2 | Diacylglycerol acyltransferase inhibitors | MADRIGAL PHARMACEUTICALS, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100113782-A1 | Diacylglycerol Acyltransferase Inhibitors | MADRIGAL PHARMACEUTICALS, INC. | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113782-A1 | Diacylglycerol Acyltransferase Inhibitors | DGAT2, DGAT1, MOGAT2 | RAB9A 2586/4885SMN1; SMN2 4749/4885ALDH1A1 802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.