Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 15/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 12/20 | 0.44 |
| ▸ | AR | P10275 | 5/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2394873 | 0.94 | PGR (0.45) | PGRNR3C1ARESR1ESR2 | |
| SCHEMBL2394160 | 0.89 | PGR (0.43) | PGRNR3C1ARESR1ESR2 | |
| SCHEMBL1315515 | 0.85 | PGR (0.41) | PGRNR3C1ARESR1ESR2 | |
| SCHEMBL2393993 | 0.85 | PGR (0.43) | PGRNR3C1ARESR1ESR2 | |
| SCHEMBL1314691 | 0.84 | NR3C1 (0.41) | PGRNR3C1ARESR1ESR2 | |
| SCHEMBL2395415 | 0.83 | PGR (0.45) | PGRNR3C1ARESR1ESR2 | |
| SCHEMBL2392224 | 0.83 | NR3C1 (0.45) | PGRNR3C1ARESR1ESR2 | |
| SCHEMBL1313997 | 0.83 | MAPT (0.46) | PGRNR3C1ARESR1ESR2 | |
| SCHEMBL2397507 | 0.83 | KDM4E (0.47) | PGRNR3C1ARESR1ESR2 | |
| SCHEMBL2398052 | 0.83 | PGR (0.46) | PGRNR3C1ARESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2319835-B1 | GLUCOCORTICOID RECEPTOR AGONIST COMPOSED OF 2,2,4-TRIMETHYL-6-PHENYL-1,2-DIHYDROQUINOLINE DERIVATIVE HAVING SUBSTITUTED OXY GROUP | AYUMI PHARMACEUTICAL CORP (JP) | 2016-04-13 | — | — | EP | disclosed |
| EP-2085388-B1 | NOVEL 1,2-DIHYDROQUINOLINE DERIVATIVE HAVING SUBSTITUTED PHENYLAMINO LOWER ALKYL GROUP AND ESTER-INTRODUCED PHENYL GROUP AS SUBSTITUENTS | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-09-05 | — | — | EP | disclosed |
| EP-2319835-A1 | GLUCOCORTICOID RECEPTOR AGONIST COMPOSED OF 2,2,4-TRIMETHYL-6-PHENYL-1,2-DIHYDROQUINOLINE DERIVATIVE HAVING SUBSTITUTED OXY GROUP | Santen Pharmaceutical Co., Ltd (JP) | 2011-05-11 | — | — | EP | disclosed |
| EP-2085388-A1 | NOVEL 1,2-DIHYDROQUINOLINE DERIVATIVE HAVING SUBSTITUTED PHENYLAMINO LOWER ALKYL GROUP AND ESTER-INTRODUCED PHENYL GROUP AS SUBSTITUENTS | Santen Pharmaceutical Co., Ltd (JP) | 2009-08-05 | — | — | EP | disclosed |