Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | FABP4 | P15090 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1844126 | 0.88 | ADRA2A (0.55) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL1845396 | 0.83 | ADRA2A (0.62) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL1846157 | 0.81 | MEN1 (0.45) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL1845121 | 0.81 | LMNA (0.43) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL12660195 | 0.81 | TAAR1 (0.46) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL1846184 | 0.80 | TAAR1 (0.50) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL1846409 | 0.78 | ADRA2A (0.56) | ADRA2AADRA2CLMNAALDH1A1CYP3A4 | |
| SCHEMBL1848615 | 0.77 | HSD17B10 (0.58) | LMNAALOX15HDAC3HDAC1HDAC2 | |
| SCHEMBL1847393 | 0.76 | SMN1; SMN2 (0.51) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL1846914 | 0.75 | KMT2A (0.41) | ADRA2AADRA2CADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101557810-B | Novel 2 -imidazoles as ligands for trace amine associated receptors (taar) | HOFFMANN LA ROCHE | 2012-11-21 | — | — | CN | claimed |
| CN-101557810-A | Novel 2 -imidazoles as ligands for trace amine associated receptors (taar) | HOFFMANN LA ROCHE (CH) | 2009-10-14 | — | — | CN | claimed |
| EP-2101762-A1 | NOVEL 2 -IMIDAZOLES AS LIGANDS FOR TRACE AMINE ASSOCIATED RECEPTORS (TAAR) | F. Hoffmann-Roche AG (CH) | 2009-09-23 | — | — | EP | claimed |
| WO-2008071574-A1 | NOVEL 2 -IMIDAZOLES AS LIGANDS FOR TRACE AMINE ASSOCIATED RECEPTORS (TAAR) | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-19 | — | — | WO | claimed |
| US-20080146634-A1 | 2-IMIDAZOLES | HOFFMANN-LA ROCHE INC. | 2008-06-19 | — | — | US | claimed |
| CN-101557810-B | Novel 2 -imidazoles as ligands for trace amine associated receptors (taar) | HOFFMANN LA ROCHE | 2012-11-21 | — | — | CN | disclosed |
| EP-2101762-B1 | NOVEL 2 -IMIDAZOLES AS LIGANDS FOR TRACE AMINE ASSOCIATED RECEPTORS (TAAR) | HOFFMANN LA ROCHE (CH) | 2011-05-18 | — | — | EP | disclosed |
| US-7858653-B2 | 2-imidazoles | HOFFMAN-LA ROCHE INC. (US) | 2010-12-28 | — | — | US | disclosed |
| US-7858653-B2 | 2-imidazoles | HOFFMAN-LA ROCHE INC. (US) | 2010-12-28 | — | — | US | disclosed |
| CN-101557810-A | Novel 2 -imidazoles as ligands for trace amine associated receptors (taar) | HOFFMANN LA ROCHE (CH) | 2009-10-14 | — | — | CN | disclosed |
| EP-2101762-A1 | NOVEL 2 -IMIDAZOLES AS LIGANDS FOR TRACE AMINE ASSOCIATED RECEPTORS (TAAR) | F. Hoffmann-Roche AG (CH) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008071574-A1 | NOVEL 2 -IMIDAZOLES AS LIGANDS FOR TRACE AMINE ASSOCIATED RECEPTORS (TAAR) | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-19 | — | — | WO | disclosed |
| US-20080146634-A1 | 2-IMIDAZOLES | HOFFMANN-LA ROCHE INC. | 2008-06-19 | — | — | US | disclosed |
| US-20080146634-A1 | 2-IMIDAZOLES | HOFFMANN-LA ROCHE INC. | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146634-A1 | 2-IMIDAZOLES | ABL1, H1-2, IPO4 | ADRA2A 84/4885ADRA2C 13/4885ADRA1D 171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.