Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.37 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.37 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.37 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.33 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3709009 | 1.00 | HDAC1 (0.39) | HDAC1HDAC6PTGDR2PLAAT3PLAAT5 | |
| SCHEMBL9955949 | 0.89 | MEN1 (0.38) | HDAC1HDAC6PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL1845524 | 0.88 | HDAC1 (0.39) | HDAC1HDAC6PTGDR2PLAAT3PLAAT5 | |
| SCHEMBL1845523 | 0.88 | HDAC1 (0.39) | HDAC1HDAC6PTGDR2PLAAT3PLAAT5 | |
| SCHEMBL1846498 | 0.85 | TAAR1 (0.37) | HDAC1HDAC6PTGDR2MEN1KMT2A | |
| SCHEMBL1846565 | 0.79 | ALDH1A1 (0.34) | MEN1KMT2A | |
| SCHEMBL956652 | 0.78 | SMN1; SMN2 (0.34) | MEN1KMT2AALOX5CHRM2CHRM3 | |
| SCHEMBL9954703 | 0.75 | DRD2 (0.44) | PLAAT3PLAAT5PLAAT2PLAAT4TAAR1 | |
| SCHEMBL3709505 | 0.74 | THRA (0.46) | HDAC1HDAC6PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL9955077 | 0.72 | POLB (0.46) | HDAC1HDAC6PLAAT3PLAAT5PLAAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393807-A1 | CYCLIC INHIBITORS OF 11 -HYDROXYSTEROID DEHYDROGENASE 1 | Boehringer Ingelheim International GmbH (DE) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089303-A1 | CYCLIC INHIBITORS OF 11 β-HYDROXYSTEROID DEHYDROGENASE 1 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-08-12 | — | — | WO | disclosed |