Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 3/20 | 0.54 |
| ▸ | CCR5 | P51681 | 3/20 | 0.54 |
| ▸ | CCR8 | P51685 | 3/20 | 0.54 |
| ▸ | MMP2 | P08253 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | GMNN | O75496 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MMP9 | P14780 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | MMP8 | P22894 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | MTOR | P42345 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12074320 | 0.83 | MMP2 (0.56) | CCR1CCR5CCR8MMP2TSHR | |
| SCHEMBL30592746 | 0.83 | MMP2 (0.56) | CCR1CCR5CCR8MMP2TSHR | |
| SCHEMBL4148271 | 0.82 | MMP2 (0.60) | CCR1CCR5CCR8MMP2TSHR | |
| SCHEMBL4366582 | 0.81 | FABP1 (0.56) | CCR1CCR5CCR8MMP2TSHR | |
| SCHEMBL12970139 | 0.81 | FABP1 (0.56) | CCR1CCR5CCR8MMP2TSHR | |
| SCHEMBL29788812 | 0.81 | KDM4E (0.54) | CCR1CCR5CCR8MMP2TSHR | |
| SCHEMBL16581166 | 0.81 | MMP2 (0.54) | CCR1CCR5CCR8MMP2TSHR | |
| SCHEMBL12386952 | 0.81 | LMNA (0.54) | CCR1CCR5CCR8MMP2TSHR | |
| SCHEMBL20999916 | 0.81 | KDM4E (0.54) | CCR1CCR5CCR8MMP2TSHR | |
| SCHEMBL18000525 | 0.81 | KDM4E (0.54) | CCR1CCR5CCR8MMP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3328850-B1 | COMPOUNDS HAVING FLUORENE STRUCTURES | MERCK PATENT GMBH (DE) | 2020-11-11 | — | — | EP | disclosed |
| WO-2017016667-A1 | COMPOUNDS HAVING FLUORENE STRUCTURES | MERCK PATENT GMBH (DE) | 2017-02-02 | — | — | WO | disclosed |