Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | PDE2A | O00408 | 5/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1844261 | 0.80 | BRPF1 (0.43) | CCR1MAPK1BRPF1 | |
| SCHEMBL2011432 | 0.80 | BRPF1 (0.43) | CCR1MAPK1BRPF1 | |
| SCHEMBL1839734 | 0.80 | CCR1 (0.36) | CCR1KDM4EALDH1A1MAPTBRPF1 | |
| SCHEMBL1839936 | 0.80 | KDM4E (0.35) | CCR1KDM4EALDH1A1MAPTMAPK1 | |
| SCHEMBL1842532 | 0.80 | KDM4E (0.36) | CCR1KDM4EALDH1A1MAPTFGFR4 | |
| SCHEMBL1841391 | 0.80 | CCR1 (0.39) | CCR1KDM4EALDH1A1MAPTFGFR4 | |
| SCHEMBL1844082 | 0.80 | ALDH1A1 (0.45) | CCR1KDM4EALDH1A1MAPTBRPF1 | |
| SCHEMBL1842876 | 0.79 | KDM4E (0.47) | CCR1KDM4EALDH1A1MAPTBRPF1 | |
| SCHEMBL1842443 | 0.79 | MAPT (0.36) | CCR1KDM4EALDH1A1MAPTMAPK1 | |
| SCHEMBL1842383 | 0.78 | CCR1 (0.36) | CCR1KDM4EALDH1A1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091944-B1 | SUBSTITUTED BICYCLOCARBOXYAMIDE COMPOUNDS | PFIZER (US) | 2011-05-18 | — | — | EP | claimed |