Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 5/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16930132 | 0.88 | REN (0.54) | REN | |
| SCHEMBL29840539 | 0.88 | REN (0.54) | REN | |
| SCHEMBL18425645 | 0.88 | REN (0.54) | REN | |
| SCHEMBL16930224 | 0.84 | ALOX15 (0.59) | ALOX15ALOX12KDM4EPOLB | |
| SCHEMBL10119254 | 0.82 | REN (0.52) | RENALOX15ALOX12KDM4EPOLB | |
| SCHEMBL19087147 | 0.80 | SIGMAR1 (0.45) | RENSIGMAR1KDM4EPOLBTUBB1 | |
| SCHEMBL16930273 | 0.78 | SIGMAR1 (0.55) | RENSIGMAR1KDM4E | |
| SCHEMBL22899046 | 0.78 | ALOX15 (0.55) | RENALOX15ALOX12 | |
| SCHEMBL21066487 | 0.78 | SIGMAR1 (0.55) | RENSIGMAR1KDM4E | |
| SCHEMBL30472720 | 0.78 | SIGMAR1 (0.55) | RENSIGMAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017016960-A1 | PROCESS FOR THE PREPARATION OF (6S)-6-ALKYL-10-ALKOXY-9-(SUBSTITUTED ALKOXY)-2-OXO-6,7-DIHYDROBENZO[A]QUINOLIZINE-3-CARBOXYLIC ACID ANALOGUES | F. HOFFMANN-LA ROCHE AG (CH) | 2017-02-02 | — | — | WO | disclosed |