Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | REN | P00797 | 7/20 | 0.44 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17709266 | 0.90 | REN (0.48) | SIGMAR1REN | |
| SCHEMBL19087186 | 0.87 | ALDH1A1 (0.37) | SIGMAR1KDM4EPOLBREN | |
| SCHEMBL17709353 | 0.81 | REN (0.46) | SIGMAR1REN | |
| SCHEMBL17709279 | 0.81 | SIGMAR1 (0.49) | SIGMAR1KDM4E | |
| SCHEMBL17709369 | 0.80 | REN (0.48) | SIGMAR1REN | |
| SCHEMBL16930349 | 0.80 | REN (0.50) | SIGMAR1REN | |
| SCHEMBL18457751 | 0.80 | REN (0.53) | SIGMAR1KDM4EPOLBRENTUBB1 | |
| SCHEMBL19273145 | 0.79 | SIGMAR1 (0.49) | SIGMAR1REN | |
| SCHEMBL17709380 | 0.78 | SIGMAR1 (0.50) | SIGMAR1REN | |
| SCHEMBL19831011 | 0.77 | LDHA (0.37) | SIGMAR1KDM4ERENLDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114812-A1 | COMBINATION THERAPY OF AN HBSAG INHIBITOR AND AN INTERFERON | F. HOFFMANN-LA ROCHE AG (CH) | 2017-07-06 | — | — | WO | disclosed |