SCHEMBL18458484

SCHEMBL18458484

C/C=C/CCc1ccc(-c2ccc(-c3ccccc3)cc2F)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR52 Q9Y2T5 4/20 0.40
TAAR1 Q96RJ0 1/20 0.40
HCAR2 Q8TDS4 1/20 0.40
RARB P10826 3/20 0.40
FFAR1 O14842 2/20 0.37
KCNA3 P22001 1/20 0.37
PTGS1 P23219 3/20 0.37
MEN1 O00255 2/20 0.37
PTGS2 P35354 2/20 0.37
KMT2A Q03164 2/20 0.37
FABP2 P12104 1/20 0.37
TSHR P16473 1/20 0.37
AKR1C4 P17516 1/20 0.37
ADRA2B P18089 1/20 0.37
CHRM3 P20309 1/20 0.37
HTR2C P28335 1/20 0.37
DRD3 P35462 1/20 0.37
AKR1C3 P42330 1/20 0.37
AKR1C2 P52895 1/20 0.37
AKR1C1 Q04828 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20849604 1.00 GPR52 (0.40) GPR52TAAR1HCAR2RARBFFAR1
SCHEMBL15180194 0.89 RARB (0.42) TAAR1HCAR2RARBKCNA3MAPT
SCHEMBL17402085 0.89 RARB (0.42) TAAR1HCAR2RARBKCNA3MAPT
SCHEMBL16258131 0.89 RARB (0.40) TAAR1HCAR2RARBKCNA3RARA
SCHEMBL15180192 0.89 RARB (0.40) TAAR1HCAR2RARBKCNA3RARA
SCHEMBL11957385 0.89 FFAR4 (0.39) GPR52TAAR1HCAR2RARBFFAR1
SCHEMBL16258133 0.89 FFAR4 (0.39) GPR52TAAR1HCAR2RARBFFAR1
SCHEMBL13577669 0.89 RARB (0.40) TAAR1HCAR2RARBKCNA3RARA
SCHEMBL18854994 0.88 RARB (0.36) TAAR1HCAR2RARBKCNA3RARA
SCHEMBL13239285 0.87 RARB (0.35) GPR52TAAR1HCAR2RARBRARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11873438-B2 Liquid-crystal medium MERCK PATENT GMBH (DE) 2024-01-16 US disclosed
US-20230159825-A1 LIQUID-CRYSTAL MEDIUM COMPRISING POLYMERIZABLE COMPOUNDS MERCK PATENT GMBH (DE) 2023-05-25 US disclosed
US-11655417-B2 Liquid-crystal medium MERCK PATENT GMBH (DE) 2023-05-23 US disclosed
WO-2023052283-A1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2023-04-06 WO disclosed
US-11370969-B2 Liquid-crystal medium MERCK PATENT GMBH (DE) 2022-06-28 US disclosed
US-20210222067-A1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2021-07-22 US disclosed
US-20200339882-A1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2020-10-29 US disclosed
US-20190345389-A1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2019-11-14 US disclosed
US-10344211-B2 Liquid crystal composition and liquid crystal display element using same DIC CORPORATION (JP) 2019-07-09 US disclosed
US-10208250-B2 Liquid crystal composition and liquid crystal display element using same DIC CORPORATION (JP) 2019-02-19 US disclosed
EP-3284803-B1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2019-01-23 EP disclosed
EP-3284803-A1 LIQUID-CRYSTAL MEDIUM Merck Patent GmbH (DE) 2018-02-21 EP disclosed
US-20170362506-A1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2017-12-21 US disclosed
US-20170355906-A1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY ELEMENT USING SAME DIC CORPORATION (JP) 2017-12-14 US disclosed
US-20170029700-A1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY ELEMENT USING SAME DIC CORPORATION (JP) 2017-02-02 US disclosed