Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | SCN1A | P35498 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4342856 | 0.90 | KEAP1 (0.54) | KEAP1SMN1; SMN2ALDH1A1HPGDDUSP3 | |
| SCHEMBL25948808 | 0.82 | KEAP1 (0.50) | KEAP1SMN1; SMN2ALDH1A1HPGDDUSP3 | |
| SCHEMBL24466284 | 0.82 | KEAP1 (0.50) | KEAP1SMN1; SMN2ALDH1A1HPGDDUSP3 | |
| SCHEMBL2411125 | 0.80 | KEAP1 (0.52) | KEAP1SMN1; SMN2ALDH1A1HPGDDUSP3 | |
| SCHEMBL31457403 | 0.80 | PAOX (0.44) | SMN1; SMN2ALDH1A1HPGDPAOXKMT2A | |
| SCHEMBL15732 | 0.80 | KEAP1 (0.52) | KEAP1SMN1; SMN2ALDH1A1HPGDDUSP3 | |
| SCHEMBL161681 | 0.78 | KEAP1 (0.50) | KEAP1SMN1; SMN2ALDH1A1HPGDDUSP3 | |
| SCHEMBL13851213 | 0.78 | KEAP1 (0.50) | KEAP1SMN1; SMN2ALDH1A1HPGDDUSP3 | |
| SCHEMBL4022655 | 0.78 | KEAP1 (0.50) | KEAP1SMN1; SMN2ALDH1A1HPGDDUSP3 | |
| SCHEMBL1446166 | 0.78 | KEAP1 (0.50) | KEAP1SMN1; SMN2ALDH1A1HPGDDUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4273143-B1 | DERIVATIVE OF 2,5-DIKETOPIPERAZINE COMPOUND, AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | DALIAN WZ PROBIOTICS AD HEALTH CO LTD (CN) | 2025-05-21 | — | — | EP | disclosed |
| US-20240140941-A1 | DERIVATIVE OF 2,5-DIKETOPIPERAZINE COMPOUND, AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | DALIAN WZ PROBIOTICS AD HEALTH CO., LTD (CN) | 2024-05-02 | — | — | US | disclosed |
| EP-4273143-A1 | DERIVATIVE OF 2,5-DIKETOPIPERAZINE COMPOUND, AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | Dalian WZ Probiotics AD Health Co., Ltd (CN) | 2023-11-08 | — | — | EP | disclosed |
| CN-114685456-B | 2, 5-diketopiperazine compound derivative, preparation method thereof, pharmaceutical composition and application thereof | 大连万众益生大健康有限公司 | 2023-10-10 | — | — | CN | disclosed |
| WO-2022144002-A1 | DERIVATIVE OF 2,5-DIKETOPIPERAZINE COMPOUND, AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | 大连万众益生大健康有限公司 | 2022-07-07 | — | — | WO | disclosed |
| CN-114685456-A | 2, 5-diketopiperazine compound derivative, preparation method thereof, pharmaceutical composition and application thereof | 大连万众益生大健康有限公司 | 2022-07-01 | — | — | CN | disclosed |
| US-20170029469-A1 | CYCLOSPORIN ANALOGS | ALLERGAN, INC. | 2017-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240140941-A1 | DERIVATIVE OF 2,5-DIKETOPIPERAZINE COMPOUND, AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | WEE1, WEE2, CYP51A1 | KEAP1 1025/4885SMN1; SMN2 3775/4885ALDH1A1 1962/4885 |
| US-20170029469-A1 | CYCLOSPORIN ANALOGS | CHP1, TSLP, PPP3R1 | KEAP1 4008/4885SMN1; SMN2 4747/4885ALDH1A1 4113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.