Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | IDH2 | P48735 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18463370 | 0.88 | GAA (0.56) | GAANPC1RAB9AMAPTLMNA | |
| SCHEMBL24996856 | 0.80 | GPR84 (0.42) | GAANPC1RAB9AMAPTLMNA | |
| SCHEMBL30166993 | 0.80 | GPR84 (0.42) | GAANPC1RAB9AMAPTLMNA | |
| SCHEMBL1333872 | 0.78 | MEN1 (0.51) | GAANPC1RAB9AMAPTLMNA | |
| SCHEMBL28877884 | 0.77 | MAOA (0.42) | NPC1RAB9AMAPTLMNAMEN1 | |
| SCHEMBL29967151 | 0.77 | MAOA (0.42) | NPC1RAB9AMAPTLMNAMEN1 | |
| SCHEMBL1748009 | 0.74 | CSNK1D (0.47) | MAPTTP53KDM4ECSNK1DIDH2 | |
| SCHEMBL18463385 | 0.74 | RAB9A (0.56) | GAANPC1RAB9AMAPTLMNA | |
| SCHEMBL31451819 | 0.74 | RAB9A (0.56) | GAANPC1RAB9AMAPTLMNA | |
| SCHEMBL4812260 | 0.74 | TRPV1 (0.46) | GAANPC1RAB9AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3328860-B2 | PROCESS FOR THE PREPARATION OF BENZIMIDAZO[1,2-A]BENZIMIDAZOLES | UDC IRELAND LTD (IE) | 2022-11-02 | — | — | EP | disclosed |
| EP-3328860-B1 | PROCESS FOR THE PREPARATION OF BENZIMIDAZO[1,2-A]BENZIMIDAZOLES | UDC IRELAND LTD (IE) | 2020-03-04 | — | — | EP | disclosed |
| EP-3328860-B1 | PROCESS FOR THE PREPARATION OF BENZIMIDAZO[1,2-A]BENZIMIDAZOLES | UDC IRELAND LTD (IE) | 2020-03-04 | — | — | EP | disclosed |
| US-10570136-B2 | Process for the preparation of benzimidazo[1,2-a] benzimidazoles | UDC IRELAND LIMITED (IE) | 2020-02-25 | — | — | US | disclosed |
| US-10570136-B2 | Process for the preparation of benzimidazo[1,2-a] benzimidazoles | UDC IRELAND LIMITED (IE) | 2020-02-25 | — | — | US | disclosed |
| US-20180170936-A1 | PROCESS FOR THE PREPARATION OF BENZIMIDAZO[1,2-A] BENZIMIDAZOLES | UDC IRELAND LIMITED (IE) | 2018-06-21 | — | — | US | disclosed |
| US-20180170936-A1 | PROCESS FOR THE PREPARATION OF BENZIMIDAZO[1,2-A] BENZIMIDAZOLES | UDC IRELAND LIMITED (IE) | 2018-06-21 | — | — | US | disclosed |
| WO-2017017096-A1 | PROCESS FOR THE PREPARATION OF BENZIMIDAZO[1,2-A]BENZIMIDAZOLES | UDC IRELAND LIMITED (IE) | 2017-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10570136-B2 | Process for the preparation of benzimidazo[1,2-a] benzimidazoles | CYP3A4, CYP2C19, CYP1B1 | GAA 174/4885NPC1 2735/4885RAB9A 2804/4885 |
| US-20180170936-A1 | PROCESS FOR THE PREPARATION OF BENZIMIDAZO[1,2-A] BENZIMIDAZOLES | CYP3A4, CYP2C19, CYP1B1 | GAA 174/4885NPC1 2735/4885RAB9A 2804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.