Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.50 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | GYS1 | P13807 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | ARF6 | P62330 | 2/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.36 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1279682 | 0.83 | IKBKB (0.46) | IKBKBGYS1KDM4EALDH1A1MAPT | |
| SCHEMBL2235270 | 0.81 | IKBKB (0.37) | IKBKBNOTUMIDO1KDM4EALDH1A1 | |
| SCHEMBL20837397 | 0.78 | MAPK14 (0.43) | GYS1RAB9ANOTUMIDO1KDM4E | |
| SCHEMBL15742048 | 0.76 | IKBKB (0.62) | IKBKBCHUKNPC1RAB9AAHR | |
| SCHEMBL20837302 | 0.76 | ENPP1 (0.41) | IKBKBCHUKNPC1L3MBTL1 | |
| SCHEMBL20837143 | 0.76 | IKBKB (0.43) | IKBKBNOTUMIDO1KDM4EMAPT | |
| SCHEMBL1279168 | 0.76 | L3MBTL1 (0.56) | IKBKBGYS1KDM4EALDH1A1MAPT | |
| SCHEMBL7254061 | 0.75 | IKBKB (0.39) | IKBKBNOTUMKDM4EALDH1A1 | |
| SCHEMBL20837303 | 0.75 | ENPP1 (0.48) | IKBKBRAB9ANOTUMIDO1ALDH1A1 | |
| SCHEMBL20837136 | 0.74 | IKBKB (0.37) | IKBKBNOTUML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11414442-B2 | ARF6 inhibitors and related methods | NAVIGEN, INC. (US) | 2022-08-16 | — | — | US | disclosed |
| US-11414442-B2 | ARF6 inhibitors and related methods | NAVIGEN, INC. (US) | 2022-08-16 | — | — | US | disclosed |
| US-20210017201-A1 | ARF6 INHIBITORS AND RELATED METHODS | NAVIGEN, INC. | 2021-01-21 | — | — | US | disclosed |
| US-20210017201-A1 | ARF6 INHIBITORS AND RELATED METHODS | NAVIGEN, INC. | 2021-01-21 | — | — | US | disclosed |
| CN-111886225-A | ARF6 inhibitors and related methods | 纳维根公司 | 2020-11-03 | — | — | CN | disclosed |
| EP-3672597-A2 | ARF6 INHIBITORS AND RELATED METHODS | Navigen, Inc. (US) | 2020-07-01 | — | — | EP | disclosed |
| WO-2019040499-A2 | ARF6 INHIBITORS AND RELATED METHODS | NAVIGEN, INC. (US) | 2019-02-28 | — | — | WO | disclosed |
| EP-2374791-A1 | Insecticidal 4-phenyl-1H pyrazoles | Bayer CropScience Aktiengesellschaft (DE) | 2011-10-12 | — | — | EP | disclosed |
| US-20110190365-A1 | Insecticidal 4-phenyl-1H-pyrazoles | BAYER CROP SCIENCE AG (DE) | 2011-08-04 | — | — | US | disclosed |
| EP-2321262-A1 | INSECTICIDAL 4-PHENYL-1H-PYRAZOLES | Bayer CropScience AG (DE) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010017902-A1 | INSECTICIDAL 4-PHENYL-1H-PYRAZOLES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2010-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190365-A1 | Insecticidal 4-phenyl-1H-pyrazoles | CYP4X1, CYP4B1, CYP3A4 | IKBKB 4222/4885CHUK 3906/4885GYS1 2843/4885 |
| US-20210017201-A1 | ARF6 INHIBITORS AND RELATED METHODS | ARF6, ARF1, ARF5 | IKBKB 1984/4885CHUK 1162/4885GYS1 4665/4885 |
| US-11414442-B2 | ARF6 inhibitors and related methods | ARF6, ARF1, ARF5 | IKBKB 1984/4885CHUK 1162/4885GYS1 4665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.