Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 4/20 | 0.53 |
| ▸ | APAF1 | O14727 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.50 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.50 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | CASP6 | P55212 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26368699 | 0.81 | ESR1 (0.47) | ESR1NPC1RAB9APOLBAPAF1 | |
| SCHEMBL18470143 | 0.81 | HSPA1A (0.47) | ESR1NPC1RAB9APOLBAPAF1 | |
| SCHEMBL7491321 | 0.81 | POLB (0.63) | ESR1NPC1RAB9APOLBAPAF1 | |
| SCHEMBL31167971 | 0.81 | POLB (0.63) | ESR1NPC1RAB9APOLBAPAF1 | |
| SCHEMBL16601645 | 0.78 | POLB (0.85) | ESR1NPC1RAB9APOLBAPAF1 | |
| SCHEMBL18470135 | 0.77 | KMT2A (0.47) | ESR1NPC1RAB9APOLBAPAF1 | |
| SCHEMBL21841879 | 0.76 | HSPA1A (0.51) | ESR1NPC1RAB9APOLBUSP2 | |
| SCHEMBL12108015 | 0.76 | KMT2A (0.54) | ESR1POLBUSP2KMT2AMEN1 | |
| SCHEMBL29726032 | 0.74 | ALDH1A1 (0.60) | ESR1NPC1RAB9APOLBAPAF1 | |
| SCHEMBL7597251 | 0.74 | ALDH1A1 (0.60) | ESR1NPC1RAB9APOLBAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10596164-B2 | Anti-clostridium compounds | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) | 2020-03-24 | — | — | US | disclosed |
| US-20170035750-A1 | NEW ANTI-CLOSTRIDIUM COMPOUNDS | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETEN SCHAPPELIJK ONDERZOEK TNO (NL) | 2017-02-09 | — | — | US | disclosed |
| US-20170035750-A1 | NEW ANTI-CLOSTRIDIUM COMPOUNDS | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETEN SCHAPPELIJK ONDERZOEK TNO (NL) | 2017-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10596164-B2 | Anti-clostridium compounds | CLPP, ATP5F1A, ATP5F1C | ESR1 4719/4885NPC1 4092/4885RAB9A 4710/4885 |
| US-20170035750-A1 | NEW ANTI-CLOSTRIDIUM COMPOUNDS | ANTXR2, CLPP, DAD1 | ESR1 4725/4885NPC1 3998/4885RAB9A 4554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.