Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRAT | P43155 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PLA2G2C | Q5R387 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.31 |
| ▸ | MMP1 | P03956 | 2/20 | 0.30 |
| ▸ | MMP2 | P08253 | 2/20 | 0.30 |
| ▸ | MMP3 | P08254 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21335957 | 0.82 | PLA2G2C (0.47) | CRATLMNAPLA2G2C | |
| SCHEMBL12785388 | 0.79 | MTNR1A (0.38) | CRATKDM4EMAPTTHRBALOX15 | |
| Hydrochloric Acid SCHEMBL6045018 | 0.77 | MTNR1A (0.37) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL12216792 | 0.77 | MCL1 (0.39) | MAPTMCL1LMNAALDH1A1ATM | |
| SCHEMBL21398592 | 0.76 | BMP1 (0.41) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL20886556 | 0.76 | MAPT (0.55) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL10936490 | 0.75 | CRAT (0.45) | CRATKDM4EMAPTTHRBALOX15 | |
| SCHEMBL15514478 | 0.71 | LMNA (0.36) | KDM4EMAPTSMN1; SMN2MCL1LMNA | |
| SCHEMBL11311284 | 0.71 | MGAM (0.44) | CRATKDM4EMAPTTHRBALOX15 | |
| SCHEMBL4903843 | 0.71 | ATM (0.34) | MAPTMCL1LMNAATMPSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210340210-A1 | CONJUGATES OF AN IL-2 MOIETY AND A POLYMER | NEKTAR THERAPEUTICS (US) | 2021-11-04 | — | — | US | disclosed |
| US-11141465-B2 | Method of making a water-soluble polymer-factor VIII moiety conjugate | NEKTAR THERAPEUTICS (US) | 2021-10-12 | — | — | US | disclosed |
| US-11091525-B2 | Method of refolding an interleukin-2 (IL-2) protein | NEKTAR THERAPEUTICS (US) | 2021-08-17 | — | — | US | disclosed |
| US-10960079-B2 | Conjugates of an IL-2 moiety and a polymer | NEKTAR THERAPEUTICS (US) | 2021-03-30 | — | — | US | disclosed |
| US-20210023230-A1 | CONJUGATES OF AN IL-2 MOIETY AND A POLYMER | NEKTAR THERAPEUTICS (US) | 2021-01-28 | — | — | US | disclosed |
| US-20210023186-A1 | POLYMER FACTOR IX MOIETY CONJUGATES | NEKTAR THERAPEUTICS (US) | 2021-01-28 | — | — | US | disclosed |
| US-10232042-B2 | Conjugates of an anti-TNF-alpha antibody | NEKTAR THERAPEUTICS (US) | 2019-03-19 | — | — | US | disclosed |
| US-20190070251-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NEKTAR THERAPEUTICS | 2019-03-07 | — | — | US | disclosed |
| US-20180207286-A1 | CONJUGATES OF A CHOLINESTERASE MOIETY AND A POLYMER | NEKTAR THERAPEUTICS | 2018-07-26 | — | — | US | disclosed |
| US-9999657-B2 | Polymer-factor VIII moiety conjugates | NEKTAR THERAPEUTICS (US) | 2018-06-19 | — | — | US | disclosed |
| US-20180085468-A1 | CONJUGATES OF AN IL-2 MOIETY AND A POLYMER | NEKTAR THERAPEUTICS | 2018-03-29 | — | — | US | disclosed |
| US-9763995-B2 | Polymer conjugates of protegrin peptides | NEKTAR THERAPEUTICS (US) | 2017-09-19 | — | — | US | disclosed |
| US-20170196975-A1 | CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY | NEKTAR THERAPEUTICS | 2017-07-13 | — | — | US | disclosed |
| US-9682153-B2 | Polymer conjugates of therapeutic peptides | NEKTAR THERAPEUTICS (US) | 2017-06-20 | — | — | US | disclosed |
| US-9636412-B2 | Conjugates of an anti-TNF-alpha antibody | NEKTAR THERAPEUTICS (US) | 2017-05-02 | — | — | US | disclosed |
| US-20170035896-A1 | POLYMER FACTOR IX MOIETY CONJUGATES | NEKTAR THERAPEUTICS | 2017-02-09 | — | — | US | disclosed |
| US-20170035898-A1 | CONJUGATES OF AN IL-15 MOIETY AND A POLYMER | NEKTAR THERAPEUTICS | 2017-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210340210-A1 | CONJUGATES OF AN IL-2 MOIETY AND A POLYMER | IL2, IL2RA, ILF2 | CRAT 4378/4885KDM4E 4220/4885MAPT 1364/4885 |
| US-10960079-B2 | Conjugates of an IL-2 moiety and a polymer | IL2, IL2RA, ILF2 | CRAT 4378/4885KDM4E 4220/4885MAPT 1364/4885 |
| US-11091525-B2 | Method of refolding an interleukin-2 (IL-2) protein | IL2, IL2RA, ILF2 | CRAT 4261/4885KDM4E 4646/4885MAPT 668/4885 |
| US-20170035896-A1 | POLYMER FACTOR IX MOIETY CONJUGATES | F9, F13A1, F8 | CRAT 4102/4885KDM4E 3324/4885MAPT 2188/4885 |
| US-20170196975-A1 | CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY | TNF, TNFRSF1A, TNFRSF9 | CRAT 3796/4885KDM4E 4660/4885MAPT 662/4885 |
| US-20180085468-A1 | CONJUGATES OF AN IL-2 MOIETY AND A POLYMER | IL2, IL2RA, ILF2 | CRAT 4378/4885KDM4E 4220/4885MAPT 1364/4885 |
| US-20180207286-A1 | CONJUGATES OF A CHOLINESTERASE MOIETY AND A POLYMER | BCHE, ACHE, DNPEP | CRAT 90/4885KDM4E 2124/4885MAPT 403/4885 |
| US-20190070251-A1 | POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES | NGLY1, CD44, IAPP | CRAT 4001/4885KDM4E 4758/4885MAPT 405/4885 |
| US-20210023230-A1 | CONJUGATES OF AN IL-2 MOIETY AND A POLYMER | IL2, IL2RA, ILF2 | CRAT 4378/4885KDM4E 4220/4885MAPT 1364/4885 |
| US-20210023186-A1 | POLYMER FACTOR IX MOIETY CONJUGATES | F9, F13A1, F8 | CRAT 4102/4885KDM4E 3324/4885MAPT 2188/4885 |
| US-20170035898-A1 | CONJUGATES OF AN IL-15 MOIETY AND A POLYMER | IL15, IL15RA, IL2 | CRAT 3873/4885KDM4E 4433/4885MAPT 1315/4885 |
| US-10232042-B2 | Conjugates of an anti-TNF-alpha antibody | TNF, TNFRSF1A, TNFRSF9 | CRAT 3796/4885KDM4E 4660/4885MAPT 662/4885 |
| US-11141465-B2 | Method of making a water-soluble polymer-factor VIII moiety conjugate | F8, F13B, F13A1 | CRAT 2828/4885KDM4E 3058/4885MAPT 3033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.