Sugi Predict

Sugi Predict / Compounds / SCHEMBL1847853

SCHEMBL1847853

SCHEMBL1847853

OC1CCCC1NCc1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ LTA4H P09960 3/20 0.58
▸ FUCA1 P04066 2/20 0.51
▸ KDM1A O60341 1/20 0.50
▸ MAOA P21397 1/20 0.50
▸ USP2 O75604 1/20 0.47
▸ ALDH1A1 P00352 1/20 0.47
▸ HPGD P15428 1/20 0.47
▸ GRIN2B Q13224 2/20 0.46
▸ CD274 Q9NZQ7 3/20 0.44
▸ PDCD1LG2 Q9BQ51 1/20 0.43
▸ BCHE P06276 1/20 0.42
▸ ACHE P22303 1/20 0.42
▸ BACE1 P56817 1/20 0.42
▸ FYN P06241 1/20 0.42
▸ PDCD1 Q15116 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9791812 1.00 LTA4H (0.58) LTA4HFUCA1KDM1AMAOAUSP2
SCHEMBL13634413 1.00 LTA4H (0.58) LTA4HFUCA1KDM1AMAOAUSP2
SCHEMBL15818134 1.00 LTA4H (0.58) LTA4HFUCA1KDM1AMAOAUSP2
SCHEMBL14001426 0.96 LTA4H (0.58) LTA4HFUCA1KDM1AMAOAHPGD
SCHEMBL15921601 0.96 LTA4H (0.58) LTA4HFUCA1KDM1AMAOAHPGD
SCHEMBL697762 0.96 LTA4H (0.58) LTA4HFUCA1KDM1AMAOAHPGD
SCHEMBL1755583 0.96 LTA4H (0.58) LTA4HFUCA1KDM1AMAOAHPGD
SCHEMBL15780394 0.96 LTA4H (0.58) LTA4HFUCA1KDM1AMAOAHPGD
SCHEMBL697761 0.96 LTA4H (0.58) LTA4HFUCA1KDM1AMAOAHPGD
SCHEMBL1361936 0.96 LTA4H (0.58) LTA4HFUCA1KDM1AMAOAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117658830-A Preparation method of trans-2-aminocyclopentanol with high optical purity 大连双硼医药化工有限公司 2024-03-08 — — CN disclosed
EP-2935263-B1 SUBSTITUTED IMIDAZOPYRIDINES AS HDM2 INHIBITORS MERCK SHARP & DOHME (US) 2018-12-05 — — EP disclosed
EP-2951180-B1 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS MERCK SHARP & DOHME (US) 2018-05-02 — — EP disclosed
CN-105073746-B Substituted imidazopyridines as HDM2 inhibitors 默沙东公司 2017-03-22 — — CN disclosed
US-9540377-B2 2,6,7,8 substituted purines as HDM2 inhibitors MERCK SHARP & DOHME CORP. (US) 2017-01-10 — — US disclosed
US-20150353553-A1 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS MERCK SHARP & DOHME CORP. (US) 2015-12-10 — — US disclosed
CN-105073746-A Substituted imidazopyridines as HDM2 inhibitors MERCK SHARP & DOHME 2015-11-18 — — CN disclosed
EP-2935263-A1 SUBSTITUTED IMIDAZOPYRIDINES AS HDM2 INHIBITORS Merck Sharp & Dohme Corp. (US) 2015-10-28 — — EP disclosed
US-8962611-B2 Substituted imidazopyridines as HDM2 inhibitors MERCK SHARP & DOHME CORP. (US) 2015-02-24 — — US disclosed
US-20140357618-A1 SUBSTITUTED IMIDAZOPYRIDINES AS HDM2 INHIBITORS MERCK SHARP & DOHME LLC 2014-12-04 — — US disclosed
US-8846657-B2 Substituted imidazopyridines as HDM2 inhibitors MERCK SHARP & DOHME CORP. (US) 2014-09-30 — — US disclosed
WO-2014100065-A1 SUBSTITUTED IMIDAZOPYRIDINES AS HDM2 INHIBITORS MERCK SHARP & DOHME CORP. (US) 2014-06-26 — — WO disclosed
US-20140179680-A1 Substituted Imidazopyridines as HDM2 Inhibitors MERCK SHARP & DOHME LLC 2014-06-26 — — US disclosed
CN-102186812-A Methods for preparing fluoroalkyl arylsulfinyl compounds and fluorinated compounds thereto UBE INDUSTRIES 2011-09-14 — — CN disclosed
US-20110190511-A1 Methods For Preparing Fluoroalkyl Arylsulfinyl Compounds And Fluorinated Compounds Thereto IM&T RESEARCH, INC. (US) 2011-08-04 — — US disclosed
EP-2323974-A1 METHODS FOR PREPARING FLUOROALKYL ARYLSULFINYL COMPOUNDS AND FLUORINATED COMPOUNDS THERETO Ube Industries, Ltd. (JP) 2011-05-25 — — EP disclosed
US-20100152463-A1 Methods for Preparing Fluoroalkyl Arylsulfinyl Compounds and Fluorinated Compounds Thereto IM&T RESEARCH, INC. (US) 2010-06-17 — — US disclosed
WO-2010022001-A1 METHODS FOR PREPARING FLUOROALKYL ARYLSULFINYL COMPOUNDS AND FLUORINATED COMPOUNDS THERETO IM&T RESEARCH, INC. (US) 2010-02-25 — — WO disclosed
EP-0121972-B1 N-ARYL-ALPHA-AMINO-CARBOXAMIDES JANSSEN PHARMACEUTICA N.V. (BE) 1989-05-24 — — EP disclosed
EP-0121972-A2 N-aryl-alpha-amino-carboxamides JANSSEN PHARMACEUTICA N.V. (BE) 1984-10-17 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140179680-A1 Substituted Imidazopyridines as HDM2 Inhibitors DDX21, ING2, MDM2 LTA4H 3642/4885FUCA1 4754/4885KDM1A 273/4885
US-20100152463-A1 Methods for Preparing Fluoroalkyl Arylsulfinyl Compounds and Fluorinated Compounds Thereto PFAS, AGPS, FDPS LTA4H 1679/4885FUCA1 666/4885KDM1A 3687/4885
US-20110190511-A1 Methods For Preparing Fluoroalkyl Arylsulfinyl Compounds And Fluorinated Compounds Thereto PFAS, AGPS, FDPS LTA4H 3533/4885FUCA1 1521/4885KDM1A 3717/4885
US-20150353553-A1 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS DDX21, DPYD, NSUN2 LTA4H 3476/4885FUCA1 4540/4885KDM1A 406/4885
US-20140357618-A1 SUBSTITUTED IMIDAZOPYRIDINES AS HDM2 INHIBITORS DDX21, ING2, MDM2 LTA4H 3642/4885FUCA1 4754/4885KDM1A 273/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.