Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | EP300 | Q09472 | 3/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | DAGLA | Q9Y4D2 | 3/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.32 |
| ▸ | DAGLB | Q8NCG7 | 2/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | IDH2 | P48735 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1847477 | 0.92 | EPHX2 (0.33) | TACR1EPHX2EP300CNR1DAGLA | |
| SCHEMBL1850509 | 0.83 | HDAC1 (0.38) | TACR1EPHX2EP300CNR1ROCK2 | |
| SCHEMBL1848054 | 0.81 | PRKAB2 (0.38) | TACR1EPHX2EP300CNR1ROCK2 | |
| SCHEMBL1847881 | 0.81 | CNR1 (0.41) | TACR1CNR1 | |
| SCHEMBL1847448 | 0.80 | LMNA (0.34) | TACR1EPHX2EP300CNR1ROCK2 | |
| SCHEMBL1848627 | 0.80 | ROCK2 (0.38) | TACR1EPHX2EP300CNR1ROCK2 | |
| SCHEMBL1846542 | 0.80 | EP300 (0.35) | EPHX2EP300CNR1DAGLABCL2L1 | |
| SCHEMBL1847877 | 0.78 | EP300 (0.37) | EPHX2EP300ROCK2BCL2L1MCL1 | |
| SCHEMBL1847077 | 0.77 | EP300 (0.36) | TACR1EP300 | |
| SCHEMBL1852052 | 0.77 | EP300 (0.39) | TACR1EPHX2EP300CNR1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410137-B2 | Thiophene-2-carboxamide derivatives, preparation thereof and therapeutic use thereof | SANOFI (FR) | 2013-04-02 | — | — | US | disclosed |
| EP-2324015-A2 | THIOPHENE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-aventis (FR) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010012964-A2 | THIOPHENE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-02-04 | — | — | WO | disclosed |