Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27833498 | 0.81 | RAB9A (0.49) | CYP3A4ALDH1A1NPC1RAB9ANOS3 | |
| SCHEMBL1844533 | 0.80 | EPHX2 (0.58) | ALDH1A1EPHX2MAPTNPC1RAB9A | |
| SCHEMBL12661738 | 0.79 | ALDH1A1 (0.44) | ALDH1A1HPGDPAK1EPHX2NPSR1 | |
| SCHEMBL28791583 | 0.78 | MEN1 (0.48) | RAB9ANOS3NOS1NOS2MEN1 | |
| SCHEMBL4693278 | 0.76 | MAPT (0.51) | ALDH1A1PAK1EPHX2NPSR1MAPT | |
| SCHEMBL5969516 | 0.75 | EPHX2 (0.54) | CYP3A4ALDH1A1EPHX2NPSR1NPC1 | |
| SCHEMBL20141057 | 0.75 | ALDH1A1 (0.41) | ALDH1A1HPGDEPHX2NPSR1USP2 | |
| SCHEMBL16795443 | 0.74 | ROCK2 (0.44) | CYP3A4HPGDNPSR1USP2MAPT | |
| SCHEMBL25291355 | 0.73 | CCNK (0.39) | ALDH1A1HPGDNPSR1USP2MAPT | |
| SCHEMBL25232523 | 0.73 | KMT2A (0.47) | ALDH1A1PAK1NPSR1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2325183-A1 | 4-(2-Furoyl) Aminopiperidine compound useful as therapeutic agent for itching | Kyorin Pharmaceutical Co., Ltd. (JP) | 2011-05-25 | — | — | EP | disclosed |
| US-7601843-B2 | 4-(2-furoyl)aminopiperidine compound useful as therapeutic agent for itching | KYORIN PHARMACEUTICAL CO., LTD (JP) | 2009-10-13 | — | — | US | disclosed |
| US-20060270632-A1 | 4-(2-Furoyl) aminopiperidine compound useful as therapeutic agent for itching | KYORIN PHARMACEUTICAL CO., LTD NISSHIN SEIFUN GROUP INC. | 2006-11-30 | — | — | US | disclosed |
| EP-1621538-A1 | 4-(2-FUROYL)AMINOPIPERIDINE COMPOUND USEFUL AS THERAPEUTIC AGENT FOR ITCHING | Kyorin Pharmaceutical Co., Ltd. (JP) | 2006-02-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270632-A1 | 4-(2-Furoyl) aminopiperidine compound useful as therapeutic agent for itching | HRH4, HRH3, HRH2 | CYP3A4 585/4885CYP2D6 936/4885ALDH1A1 2669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.