Sugi Predict

Sugi Predict / Compounds / Quinoline

Quinoline

Quinoline

SCHEMBL1848150

CCOC(C)OCC.c1ccc2ncccc2c1

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 6/20 0.59
▸ LMNA P02545 2/20 0.41
▸ PDE10A Q9Y233 1/20 0.41
▸ CYP3A4 P08684 2/20 0.40
▸ POLB P06746 2/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ SMN1; SMN2 Q16637 2/20 0.39
▸ PDGFRB P09619 1/20 0.39
▸ PDGFRA P16234 1/20 0.39
▸ TLR8 Q9NR97 2/20 0.38
▸ MPO P05164 1/20 0.37
▸ HTT P42858 3/20 0.37
▸ CASP1 P29466 2/20 0.37
▸ MEN1 O00255 2/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ CASP7 P55210 1/20 0.37
▸ CYP1A2 P05177 1/20 0.37
▸ CYP2C19 P33261 1/20 0.37
▸ NR4A2 P43354 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Quinoline SCHEMBL1257445 0.82 ALDH1A1 (0.68) ALDH1A1LMNAPDE10ACYP3A4POLB
Quinoline SCHEMBL2535469 0.81 ALDH1A1 (0.81) ALDH1A1LMNAPDE10ACYP3A4POLB
Quinoline SCHEMBL4599170 0.79 ALDH1A1 (0.77) ALDH1A1LMNAPDE10ACYP3A4POLB
Quinoline SCHEMBL27960167 0.79 ALDH1A1 (0.77) ALDH1A1LMNAPDE10ACYP3A4POLB
Quinoline SCHEMBL14060580 0.78 ALDH1A1 (0.68) ALDH1A1LMNAPDE10ACYP3A4POLB
Quinoline SCHEMBL28518288 0.78 ALDH1A1 (0.68) ALDH1A1LMNAPDE10ACYP3A4POLB
Quinoline SCHEMBL11151476 0.77 ALDH1A1 (0.74) ALDH1A1LMNAPDE10ACYP3A4POLB
Quinoline SCHEMBL6399465 0.77 ALDH1A1 (0.74) ALDH1A1LMNAPDE10ACYP3A4POLB
Quinoline SCHEMBL27467057 0.77 ALDH1A1 (0.74) ALDH1A1LMNAPDE10ACYP3A4POLB
Quinoline SCHEMBL28250556 0.77 ALDH1A1 (0.74) ALDH1A1LMNAPDE10ACYP3A4POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2323996-B1 LUMINOGENIC COMPOUNDS AND METHODS TO DETECT CYTOCHROME P450 3A ENZYMES PROMEGA CORP (US) 2014-10-22 — — EP disclosed
US-8288559-B2 Luminogenic compounds and methods to detect cytochrome P450 3A enzymes PROMEGA CORPORATION (US) 2012-10-16 — — US disclosed
EP-2323996-A1 LUMINOGENIC COMPOUNDS AND METHODS TO DETECT CYTOCHROME P450 3A ENZYMES Promega Corporation (US) 2011-05-25 — — EP disclosed
US-20100062470-A1 LUMINOGENIC COMPOUNDS AND METHODS TO DETECT CYTOCHROME P450 3A ENZYMES PROMEGA CORPORATION (US) 2010-03-11 — — US disclosed
WO-2010021686-A1 LUMINOGENIC COMPOUNDS AND METHODS TO DETECT CYTOCHROME P450 3A ENZYMES PROMEGA CORPORATION (US) 2010-02-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100062470-A1 LUMINOGENIC COMPOUNDS AND METHODS TO DETECT CYTOCHROME P450 3A ENZYMES CYP3A43, CYP1A1, CYP3A4 ALDH1A1 176/4885LMNA 1683/4885PDE10A 773/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.