Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.38 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18474444 | 0.82 | SLC6A3 (0.48) | SLC6A3DRD2SLC6A4MAP4K4HRH3 | |
| SCHEMBL17555897 | 0.81 | LTA4H (0.46) | MAP4K4HRH3MEN1LMNAHTT | |
| SCHEMBL18482037 | 0.79 | SLC6A3 (0.56) | SLC6A3DRD2SLC6A4MAP4K4HRH3 | |
| SCHEMBL18486943 | 0.78 | NOS1 (0.46) | MAP4K4 | |
| SCHEMBL18476441 | 0.77 | SLC6A3 (0.47) | SLC6A3DRD2SLC6A4MAP4K4HRH3 | |
| SCHEMBL3873265 | 0.72 | EHMT2 (0.44) | SLC6A3DRD2SLC6A4HRH3EHMT2 | |
| SCHEMBL17555820 | 0.68 | KDM1A (0.42) | — | |
| SCHEMBL18487394 | 0.68 | ADORA2A (0.36) | MEN1KMT2A | |
| SCHEMBL18474439 | 0.68 | SLC6A3 (0.60) | SLC6A3DRD2SLC6A4HRH3LMNA | |
| SCHEMBL17555600 | 0.68 | CLK2 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017023972-A1 | 3-(1H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-1H-PYRAZOLO[4,3-B]PYRIDINES AND THERAPEUTIC USES THEREOF | SAMUMED, LLC. (US) | 2017-02-09 | — | — | WO | disclosed |