Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TNF | P01375 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18450619 | 0.81 | TNF (0.45) | LMNATNFMAPK1CYP2C9CYP2C19 | |
| SCHEMBL9380208 | 0.78 | LMNA (0.50) | LMNATNFMAPK1HTR1AADRA1D | |
| SCHEMBL5042933 | 0.77 | PKM (0.42) | LMNATNFMAPK1HTR1AADRA1D | |
| SCHEMBL440082 | 0.75 | LMNA (0.47) | LMNATNFHTR1AADRA1DADRA1A | |
| SCHEMBL18449197 | 0.74 | TNF (0.60) | TNFCYP2C9CYP2C19 | |
| SCHEMBL11061888 | 0.72 | KDM4E (0.42) | LMNAMAPK1HTR1AADRA1DADRA1A | |
| SCHEMBL27413106 | 0.71 | HTR1A (0.37) | LMNATNFMAPK1HTR1AADRA1D | |
| SCHEMBL1029308 | 0.70 | LMNA (0.36) | LMNATNFMAPK1HTR1AADRA1D | |
| SCHEMBL13074891 | 0.69 | PLG (0.43) | LMNATNFMAPK1HTR1APKM | |
| SCHEMBL9724121 | 0.69 | LMNA (0.62) | LMNAMAPK1HTR1AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017023905-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF TNF ALPHA | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-02-09 | — | — | WO | disclosed |