Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1425076 | 0.78 | GRM5 (0.39) | GRM5ALDH1A1RECQLTSHRKDM4E | |
| SCHEMBL17490785 | 0.77 | GRM5 (0.38) | GRM5ALDH1A1RECQLTSHRKDM4E | |
| SCHEMBL18506604 | 0.77 | KDM4E (0.39) | GRM5ALDH1A1RECQLTSHRKDM4E | |
| SCHEMBL1425100 | 0.77 | GRM5 (0.38) | GRM5ALDH1A1RECQLTSHRKDM4E | |
| SCHEMBL18517735 | 0.75 | CTSK (0.47) | — | |
| SCHEMBL1179216 | 0.74 | KDM4E (0.45) | GRM5ALDH1A1RECQLTSHRKDM4E | |
| SCHEMBL1336479 | 0.71 | KDM4E (0.40) | ALDH1A1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL18489423 | 0.70 | LMNA (0.31) | — | |
| SCHEMBL2408915 | 0.70 | MBOAT4 (0.38) | GRM5CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL17386207 | 0.69 | KMT2A (0.41) | ALDH1A1KDM4EPOLBL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3341370-B1 | CGRP RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2021-04-28 | — | — | EP | disclosed |
| EP-3334721-B1 | CGRP RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2021-04-28 | — | — | EP | disclosed |
| CN-107922385-B | CGRP receptor antagonists | 伊莱利利公司 | 2020-09-08 | — | — | CN | disclosed |
| CN-107922406-B | CGRP receptor antagonists | 伊兰科美国公司 | 2020-04-03 | — | — | CN | disclosed |
| EP-3341370-A1 | CGRP RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2018-07-04 | — | — | EP | disclosed |
| EP-3334721-A1 | CGRP RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2018-06-20 | — | — | EP | disclosed |
| US-9708297-B2 | CGRP receptor antagonists | ELI LILLY AND COMPANY (US) | 2017-07-18 | — | — | US | disclosed |
| US-9637495-B2 | CGRP receptor antagonists | ELI LILLY AND COMPANY (US) | 2017-05-02 | — | — | US | disclosed |
| WO-2017027343-A1 | CGRP RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2017-02-16 | — | — | WO | disclosed |
| US-20170044138-A1 | CGRP RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY | 2017-02-16 | — | — | US | disclosed |
| WO-2017027345-A1 | CGRP RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2017-02-16 | — | — | WO | disclosed |
| US-20170044163-A1 | CGRP RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY | 2017-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170044163-A1 | CGRP RECEPTOR ANTAGONISTS | CALCRL, CALCR, CCKBR | GRM5 352/4885ALDH1A1 1467/4885RECQL 4042/4885 |
| US-20170044138-A1 | CGRP RECEPTOR ANTAGONISTS | CALCRL, CALCR, CCKBR | GRM5 352/4885ALDH1A1 1467/4885RECQL 4042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.