Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 6/20 | 0.53 |
| ▸ | S1PR5 | Q9H228 | 6/20 | 0.52 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1848386 | 0.84 | GPR52 (0.50) | GPR52S1PR5S1PR4CES2PNMT | |
| SCHEMBL3198656 | 0.83 | GPR52 (0.49) | GPR52S1PR5S1PR4CES2AKR1C3 | |
| SCHEMBL1853402 | 0.82 | GPR52 (0.75) | GPR52S1PR5S1PR4 | |
| SCHEMBL1849010 | 0.82 | GPR52 (0.54) | GPR52S1PR5S1PR4KDM4EMEN1 | |
| SCHEMBL1847713 | 0.81 | GPR52 (0.62) | GPR52S1PR5S1PR4KDM4EMEN1 | |
| SCHEMBL3206554 | 0.80 | GPR52 (0.46) | GPR52S1PR5S1PR4CES2AKR1C3 | |
| SCHEMBL1854277 | 0.80 | S1PR5 (0.63) | GPR52S1PR5S1PR4AKR1C3AKR1C2 | |
| SCHEMBL1850062 | 0.80 | MRGPRX4 (0.57) | GPR52S1PR5S1PR4 | |
| SCHEMBL1850455 | 0.79 | GPR52 (0.49) | GPR52S1PR5S1PR4CES2AKR1C3 | |
| SCHEMBL1847866 | 0.77 | GPR52 (0.51) | GPR52S1PR5S1PR4AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323978-A1 | AMIDE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010018874-A1 | AMIDE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-02-18 | — | — | WO | disclosed |