Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18488826 | 0.83 | RAPGEF4 (0.44) | RAPGEF4PTGER2 | |
| SCHEMBL18451634 | 0.70 | GAA (0.39) | RAPGEF4 | |
| SCHEMBL27421855 | 0.68 | RAPGEF4 (0.46) | RAPGEF4FFAR4 | |
| SCHEMBL19880452 | 0.68 | RAPGEF4 (0.46) | RAPGEF4FFAR4 | |
| SCHEMBL13999724 | 0.67 | MAOA (0.39) | RAPGEF4PTGER2 | |
| SCHEMBL23491264 | 0.67 | ALDH1A1 (0.51) | RAPGEF4 | |
| SCHEMBL14290382 | 0.67 | RAPGEF4 (0.57) | RAPGEF4FFAR4 | |
| SCHEMBL19779362 | 0.65 | RAPGEF4 (0.42) | RAPGEF4FFAR4 | |
| SCHEMBL19880471 | 0.62 | MEN1 (0.42) | RAPGEF4FFAR4 | |
| SCHEMBL18190919 | 0.62 | GRIN2D (0.42) | RAPGEF4PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017021920-A1 | DOPAMINE D3 RECEPTOR ANTAGONISTS HAVING A BICYCLO MOIETY | INDIVIOR UK LIMITED (GB) | 2017-02-09 | — | — | WO | disclosed |