Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.64 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.45 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.43 |
| ▸ | GCK | P35557 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185529 | 0.87 | GCK (0.48) | PPARGPPARAELOVL6GCKCCR6 | |
| SCHEMBL184337 | 0.85 | GCK (0.49) | PPARGPPARAGCK | |
| SCHEMBL184640 | 0.84 | GCK (0.50) | PPARGELOVL6GCKMMP13MMP8 | |
| SCHEMBL184678 | 0.83 | GCK (0.43) | PPARGGCKMMP13MEN1KMT2A | |
| SCHEMBL4576498 | 0.82 | PPARG (0.82) | PPARGPPARASLC22A12ALDH1A1MRGPRX4 | |
| SCHEMBL184976 | 0.81 | GCK (0.48) | PPARGGCKMEN1KMT2AMMP2 | |
| SCHEMBL5083539 | 0.80 | PPARG (0.80) | PPARGPPARASLC22A12ALDH1A1LMNA | |
| SCHEMBL31053289 | 0.80 | PPARG (0.80) | PPARGPPARASLC22A12ALDH1A1LMNA | |
| SCHEMBL185010 | 0.79 | GCK (0.48) | PPARGPPARAGCK | |
| SCHEMBL197390 | 0.79 | GCK (0.50) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402327-B1 | Acetamide compounds as glucokinase activators, their process and medicinal applications | IMPETIS BIOSCIENCES LTD (IN) | 2018-03-07 | — | — | EP | disclosed |
| EP-2402327-A1 | Acetamide compounds as glucokinase activators, their process and medicinal applications | Advinus Therapeutics Private Limited (IN) | 2012-01-04 | — | — | EP | disclosed |