Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 5/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 4/20 | 0.43 |
| ▸ | MMP9 | P14780 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.39 |
| ▸ | LIPE | Q05469 | 3/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185529 | 0.88 | GCK (0.48) | GCKKEAP1NFE2L2PPARG | |
| SCHEMBL197390 | 0.86 | GCK (0.50) | GCKKEAP1NFE2L2 | |
| SCHEMBL184640 | 0.85 | GCK (0.50) | GCKPPARG | |
| SCHEMBL184906 | 0.84 | MMP13 (0.51) | GCKKEAP1NFE2L2MMP2MMP9 | |
| SCHEMBL184731 | 0.84 | GCK (0.50) | GCKKEAP1NFE2L2KMT2A | |
| SCHEMBL184498 | 0.84 | GCK (0.63) | GCKKEAP1NFE2L2PPARGMEN1 | |
| SCHEMBL185010 | 0.82 | GCK (0.48) | GCKPPARG | |
| SCHEMBL184915 | 0.81 | PPARG (0.64) | GCKMMP2MMP9MMP14PPARG | |
| SCHEMBL184592 | 0.80 | GCK (0.51) | GCKMMP2MMP9PPARG | |
| SCHEMBL184497 | 0.79 | GCK (0.51) | GCKPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402327-B1 | Acetamide compounds as glucokinase activators, their process and medicinal applications | IMPETIS BIOSCIENCES LTD (IN) | 2018-03-07 | — | — | EP | disclosed |
| EP-2402327-A1 | Acetamide compounds as glucokinase activators, their process and medicinal applications | Advinus Therapeutics Private Limited (IN) | 2012-01-04 | — | — | EP | disclosed |