Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 12/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL184906 | 0.88 | MMP13 (0.51) | GCKMMP1MMP8MMP13ALDH1A1 | |
| SCHEMBL184498 | 0.88 | GCK (0.63) | GCKPPARGELOVL6 | |
| SCHEMBL184731 | 0.88 | GCK (0.50) | GCKMMP13ALDH1A1ELOVL6 | |
| SCHEMBL197390 | 0.88 | GCK (0.50) | GCK | |
| SCHEMBL184678 | 0.87 | GCK (0.43) | GCKMMP13PPARGALDH1A1 | |
| SCHEMBL184337 | 0.87 | GCK (0.49) | GCKPPARG | |
| SCHEMBL185529 | 0.85 | GCK (0.48) | GCKPPARGELOVL6 | |
| SCHEMBL184976 | 0.85 | GCK (0.48) | GCKPPARG | |
| SCHEMBL184915 | 0.84 | PPARG (0.64) | GCKMMP8MMP13PPARGALDH1A1 | |
| SCHEMBL185010 | 0.83 | GCK (0.48) | GCKPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402327-B1 | Acetamide compounds as glucokinase activators, their process and medicinal applications | IMPETIS BIOSCIENCES LTD (IN) | 2018-03-07 | — | — | EP | disclosed |
| EP-2402327-A1 | Acetamide compounds as glucokinase activators, their process and medicinal applications | Advinus Therapeutics Private Limited (IN) | 2012-01-04 | — | — | EP | disclosed |