Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23868441 | 0.86 | ALDH1A1 (0.49) | HSD17B10ALDH1A1TSHRRAB9AGAA | |
| SCHEMBL18475431 | 0.85 | CTSD (0.51) | HSD17B10ALDH1A1TSHRPOLBKMT2A | |
| SCHEMBL18475393 | 0.85 | CTSD (0.51) | HSD17B10ALDH1A1TSHRPOLBKMT2A | |
| SCHEMBL20919657 | 0.82 | SMN1; SMN2 (0.54) | HSD17B10ALDH1A1TSHRSMN1; SMN2POLB | |
| SCHEMBL21543727 | 0.82 | HCRTR1 (0.51) | HSD17B10ALDH1A1GAASMN1; SMN2KMT2A | |
| SCHEMBL19068587 | 0.81 | HTT (0.54) | HSD17B10ALDH1A1TSHRRAB9ANPC1 | |
| SCHEMBL25920599 | 0.81 | TSHR (0.52) | HSD17B10ALDH1A1TSHRRAB9ANPC1 | |
| SCHEMBL17839975 | 0.80 | HSD17B10 (0.49) | HSD17B10ALDH1A1TSHRPOLBKMT2A | |
| SCHEMBL29453458 | 0.80 | HSD17B10 (0.49) | HSD17B10ALDH1A1TSHRPOLBKMT2A | |
| SCHEMBL18445963 | 0.80 | CYP1A2 (0.49) | HSD17B10ALDH1A1TSHRRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017024317-A2 | METHODS TO INDUCE TARGETED PROTEIN DEGRADATION THROUGH BIFUNCTIONAL MOLECULES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-02-09 | — | — | WO | disclosed |