Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1698329 | 0.73 | — | — | |
| SCHEMBL7695481 | 0.72 | MAPT (0.39) | MAPTCACNA1BAPBA1TSHR | |
| SCHEMBL4119963 | 0.68 | DGAT1 (0.34) | MAPTCACNA1BAPBA1TSHR | |
| SCHEMBL28401523 | 0.68 | LMNA (0.43) | MAPTCACNA1BAPBA1TSHR | |
| SCHEMBL12500871 | 0.68 | — | — | |
| Urea SCHEMBL7200459 | 0.68 | — | — | |
| SCHEMBL19305210 | 0.68 | ALDH1A1 (0.42) | — | |
| SCHEMBL7036743 | 0.67 | TSHR (0.33) | MAPTTSHR | |
| SCHEMBL19361664 | 0.67 | TSHR (0.33) | TSHR | |
| SCHEMBL3811535 | 0.67 | TSHR (0.32) | MAPTCACNA1BAPBA1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3334738-A1 | 2-AMINO-7A-PHENYL-3,4,4A,5,7,7A-HEXAHYDROFURO[3,4-B]PYRIDINES AS BACE1 INHIBITORS | H. Lundbeck A/S (DK) | 2018-06-20 | — | — | EP | disclosed |
| WO-2017025565-A1 | 2-AMINO-7A-PHENYL-3,4,4A,5,7,7A-HEXAHYDROFURO[3,4-B]PYRIDINES AS BACE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2017-02-16 | — | — | WO | disclosed |