Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | PPM1B | O75688 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15928440 | 0.84 | ALDH1A1 (0.44) | ALDH1A1MAPK1SMN1; SMN2CYP2C19TP53 | |
| SCHEMBL5618 | 0.84 | CYP3A4 (0.49) | ALDH1A1MAPK1SMN1; SMN2CYP2C19TP53 | |
| SCHEMBL20625156 | 0.82 | KMT2A (0.38) | ALDH1A1GPR119MAPK1SMN1; SMN2CYP2C19 | |
| SCHEMBL880078 | 0.81 | ALDH1A1 (0.42) | ALDH1A1MAPK1SMN1; SMN2PPM1BPTPN1 | |
| SCHEMBL812979 | 0.80 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2LMNAPOLBPPM1B | |
| SCHEMBL813357 | 0.80 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2LMNAPOLBPPM1B | |
| SCHEMBL552606 | 0.80 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2LMNAPOLBPPM1B | |
| SCHEMBL526157 | 0.80 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2LMNAPOLBPPM1B | |
| SCHEMBL16771851 | 0.79 | ALDH1A1 (0.37) | ALDH1A1MAPK1SMN1; SMN2LMNAPOLB | |
| SCHEMBL5353054 | 0.79 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2LMNAPOLBPPM1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170107219-A1 | AZABENZIMIDAZOLE DERIVATIVE HAVING AMPK-ACTIVATING ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2017-04-20 | — | — | US | disclosed |
| US-9567330-B2 | Azabenzimidazole derivative having AMPK-activating activity | SHIONOGI & CO., LTD. (JP) | 2017-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170107219-A1 | AZABENZIMIDAZOLE DERIVATIVE HAVING AMPK-ACTIVATING ACTIVITY | PRKAB1, PRKAB2, PRKAG1 | ALDH1A1 3403/4885GPR119 49/4885MAPK1 706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.