Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 14/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 14/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 14/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 14/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 14/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 13/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 12/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 8/20 | 0.37 |
| ▸ | GABRP | O00591 | 4/20 | 0.37 |
| ▸ | GABRD | O14764 | 4/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.37 |
| ▸ | GABRE | P78334 | 4/20 | 0.37 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.37 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.37 |
| ▸ | GABRQ | Q9UN88 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18508705 | 0.85 | GABRA1 (0.41) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL2806960 | 0.85 | GABRG2 (0.50) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL4640037 | 0.68 | NPC1 (0.35) | MAPTSMN1; SMN2NPC1 | |
| SCHEMBL28819880 | 0.67 | GABRA1 (0.46) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL25007722 | 0.66 | KDM4E (0.47) | ALDH1A1MAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL28007337 | 0.66 | GABRG2 (0.43) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL26625022 | 0.64 | TDP1 (0.35) | GABRA2GABRB2ALDH1A1MAPTKDM4E | |
| SCHEMBL4640842 | 0.64 | GRIN2D (0.33) | ALDH1A1MAPTSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL4640807 | 0.64 | CA1 (0.35) | ALDH1A1MAPTSMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL4640039 | 0.64 | MEN1 (0.41) | ALDH1A1SMN1; SMN2KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168952-B1 | MORPHOLINE DERIVATIVES AS RENIN INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2017-02-15 | — | — | EP | disclosed |