Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 13/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 13/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 12/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 12/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 12/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 11/20 | 0.50 |
| ▸ | GABRA6 | Q16445 | 10/20 | 0.50 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.50 |
| ▸ | GABRP | O00591 | 1/20 | 0.50 |
| ▸ | GABRD | O14764 | 1/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.50 |
| ▸ | GABRE | P78334 | 1/20 | 0.50 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.50 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.50 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.50 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18508705 | 0.92 | GABRA1 (0.41) | GABRG2GABRB3GABRA1GABRA2GABRA5 | |
| SCHEMBL18508704 | 0.85 | GABRA1 (0.37) | GABRG2GABRB3GABRA1GABRA2GABRA5 | |
| SCHEMBL28007337 | 0.76 | GABRG2 (0.43) | GABRG2GABRB3GABRA1GABRA2GABRA5 | |
| SCHEMBL3882051 | 0.74 | DYRK1A (0.46) | GABRG2GABRB3GABRA1GABRA2GABRA5 | |
| SCHEMBL25087493 | 0.73 | GABRG2 (0.46) | GABRG2GABRB3GABRA1GABRA2GABRA5 | |
| SCHEMBL2297259 | 0.72 | GABRG2 (0.52) | GABRG2GABRB3GABRA1GABRA2GABRA5 | |
| SCHEMBL3918289 | 0.72 | GABRA1 (0.54) | GABRG2GABRB3GABRA1GABRA2GABRA5 | |
| SCHEMBL2646157 | 0.68 | SIRT6 (0.52) | GABRG2GABRB3GABRA1GABRA2GABRA5 | |
| SCHEMBL31515460 | 0.68 | SIRT6 (0.52) | GABRG2GABRB3GABRA1GABRA2GABRA5 | |
| SCHEMBL8269421 | 0.68 | TDO2 (0.40) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168952-B1 | MORPHOLINE DERIVATIVES AS RENIN INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2017-02-15 | — | — | EP | disclosed |
| US-8975252-B2 | Morpholine derivative | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2015-03-10 | — | — | US | disclosed |
| US-8975252-B2 | Morpholine derivative | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2015-03-10 | — | — | US | disclosed |
| US-8975252-B2 | Morpholine derivative | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2015-03-10 | — | — | US | disclosed |
| US-20100240644-A1 | MORPHOLINE DERIVATIVE | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2010-09-23 | — | — | US | disclosed |
| US-20100240644-A1 | MORPHOLINE DERIVATIVE | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2010-09-23 | — | — | US | disclosed |
| US-20100240644-A1 | MORPHOLINE DERIVATIVE | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2010-09-23 | — | — | US | disclosed |
| EP-2168952-A1 | MORPHOLINE DERIVATIVE | Mitsubishi Tanabe Pharma Corporation (JP) | 2010-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240644-A1 | MORPHOLINE DERIVATIVE | REN, AGTR1, AGTR2 | GABRG2 2764/4885GABRB3 2690/4885GABRA1 3416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.