Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 6/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.31 |
| ▸ | NCF1 | P14598 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR1E | P28566 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | HTR5A | P47898 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20824972 | 0.74 | EGFR (0.35) | MAPT | |
| SCHEMBL21120789 | 0.71 | TP53 (0.38) | ALOX5KDM4ECYP3A4MAPT | |
| SCHEMBL22242785 | 0.69 | ESR2 (0.42) | ALOX5KDM4EMAPT | |
| SCHEMBL18896546 | 0.69 | HMGCR (0.39) | ALOX5CYP3A4 | |
| SCHEMBL18715143 | 0.69 | MMP8 (0.50) | LOXL2KDM4ECYP3A4MAPTNOS1 | |
| SCHEMBL24862125 | 0.67 | CYP1A2 (0.48) | KDM4ECYP3A4MAPT | |
| SCHEMBL22811117 | 0.67 | MAPT (0.38) | KDM4EMAPT | |
| SCHEMBL18442003 | 0.67 | TYR (0.41) | KDM4ECYP3A4MAPT | |
| SCHEMBL3972895 | 0.66 | TRPA1 (0.41) | ALOX5KDM4EMAPTNOS1NOS2 | |
| SCHEMBL3280956 | 0.66 | ALDH1A1 (0.50) | LOXL2HTR7KDM4ECYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168952-B1 | MORPHOLINE DERIVATIVES AS RENIN INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2017-02-15 | — | — | EP | disclosed |