Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | NCF1 | P14598 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL81626 | 0.83 | PGR (0.39) | PGRSLC6A2NCF1 | |
| SCHEMBL18820341 | 0.83 | PGR (0.39) | PGRSLC6A2NCF1 | |
| SCHEMBL18820340 | 0.83 | PGR (0.39) | PGRSLC6A2NCF1 | |
| SCHEMBL8444991 | 0.75 | PGR (0.35) | PGRSLC6A2NCF1 | |
| SCHEMBL22628612 | 0.74 | PGR (0.35) | PGRSLC6A2NCF1 | |
| SCHEMBL23603451 | 0.72 | PGR (0.34) | PGRSLC6A2NCF1 | |
| SCHEMBL690380 | 0.72 | SIGMAR1 (0.39) | PGRSLC6A2NCF1 | |
| SCHEMBL690369 | 0.72 | DRD3 (0.42) | PGR | |
| SCHEMBL3467156 | 0.72 | ADH1A (0.44) | — | |
| SCHEMBL688401 | 0.71 | NCF1 (0.41) | NCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2701510-B1 | PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME | USHER III INITIATIVE INC (US) | 2017-02-15 | — | — | EP | disclosed |