SCHEMBL1851387

SCHEMBL1851387

NCc1ccc(-c2ccc(C(=O)O)cc2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 1/20 0.61
TAAR1 Q96RJ0 1/20 0.58
LOXL2 Q9Y4K0 1/20 0.57
RARB P10826 6/20 0.56
CA12 O43570 2/20 0.56
CA1 P00915 2/20 0.56
CA2 P00918 2/20 0.56
CA9 Q16790 2/20 0.56
CA14 Q9ULX7 2/20 0.56
ALDH1A1 P00352 2/20 0.54
BCL2L1 Q07817 1/20 0.54
BAD Q92934 1/20 0.54
HDAC3 O15379 1/20 0.53
HDAC6 Q9UBN7 1/20 0.53
NCOR2 Q9Y618 1/20 0.53
RXRA P19793 1/20 0.53
RXRB P28702 1/20 0.53
SRD5A2 P31213 1/20 0.53
BCL2 P10415 1/20 0.53
MEN1 O00255 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1853914 0.98 HRH3 (0.58) HRH3TAAR1LOXL2RARBCA12
Aminomethylbenzoic Acid SCHEMBL9344424 0.93 ALDH1A1 (0.60) LOXL2CA12CA1CA2CA9
Aminomethylbenzoic Acid SCHEMBL38758 0.93 ALDH1A1 (0.60) LOXL2CA12CA1CA2CA9
Aminomethylbenzoic Acid SCHEMBL7428232 0.91 ALDH1A1 (0.58) LOXL2CA12CA1CA2CA9
Aminomethylbenzoic Acid SCHEMBL1206230 0.91 ALDH1A1 (0.58) LOXL2CA12CA1CA2CA9
Aminomethylbenzoic Acid SCHEMBL28342619 0.91 ALDH1A1 (0.58) LOXL2CA12CA1CA2CA9
Aminomethylbenzoic Acid SCHEMBL1567841 0.91 ALDH1A1 (0.58) LOXL2CA12CA1CA2CA9
Aminomethylbenzoic Acid SCHEMBL11755138 0.89 ALDH1A1 (0.61) LOXL2RARBALDH1A1HDAC3HDAC6
Aminomethylbenzoic Acid SCHEMBL29271526 0.87 ALDH1A1 (0.59) LOXL2RARBALDH1A1HDAC3HDAC6
SCHEMBL26112100 0.87 SRD5A2 (0.58) LOXL2CA12CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7666979-B2 polyvalent targeting ligands that bind to cells used for diagnosis of diseases sensitivity to angiogenesis factor BRACCO INTERNATIONAL B.V. (NL) 2010-02-23 US claimed
EP-1778299-A4 METHODS FOR PREPARING MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS BRACCO INT BV (NL) 2009-08-26 EP claimed
EP-1778299-A2 METHODS FOR PREPARING MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS BRACCO INTERNATIONAL B.V. (NL) 2007-05-02 EP claimed
WO-2006096207-A2 METHODS FOR PREPARING MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS BRACCO INTERNATIONAL B.V. (NL) 2006-09-14 WO claimed
US-20050147555-A1 Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same BRACCO SUISSE SA (CH) 2005-07-07 US claimed
WO-2023196898-A1 BETA GLOBIN MIMETIC PEPTIDES AND THEIR USE THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2023-10-12 WO disclosed
CN-106795092-B Epoxy ester compound, cellulose ester resin composition, optical film and liquid crystal display device DIC株式会社 2019-05-17 CN disclosed
CN-105209942-B Phase retardation film, polarizer and liquid crystal display device 柯尼卡美能达株式会社 2018-01-30 CN disclosed
CN-105579874-B Resin composition for optical material, optical thin film and liquid crystal display device DIC株式会社 2017-09-05 CN disclosed
CN-106795092-A Epoxy ester compound, cellulose ester resin composition, optical film and liquid crystal display device DIC株式会社 2017-05-31 CN disclosed
CN-106468798-A Phase retardation film, polaroid and liquid crystal indicator 柯尼卡美能达株式会社 2017-03-01 CN disclosed
CN-105579874-A Resin composition for optical materials, optical film and liquid crystal display device DAINIPPON INK & CHEMICALS 2016-05-11 CN disclosed
EP-1778299-A4 METHODS FOR PREPARING MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS BRACCO INT BV (NL) 2009-08-26 EP disclosed
WO-2009052078-A1 CCR10 ANTAGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-04-23 WO disclosed
EP-1778299-A2 METHODS FOR PREPARING MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS BRACCO INTERNATIONAL B.V. (NL) 2007-05-02 EP disclosed
WO-2006096207-A2 METHODS FOR PREPARING MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS BRACCO INTERNATIONAL B.V. (NL) 2006-09-14 WO disclosed
US-20050147555-A1 Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same BRACCO SUISSE SA (CH) 2005-07-07 US disclosed
US-20050124656-A1 Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases(ptps) APPLIED RESEARCH SYSTEMS ARS (NL) 2005-06-09 US disclosed
EP-1470102-A1 SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) Applied Research Systems ARS Holding N.V. (AN) 2004-10-27 EP disclosed
WO-2003064376-A1 SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2003-08-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050147555-A1 Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same LDHB, FPGS, MTHFD2 HRH3 2716/4885TAAR1 4205/4885LOXL2 3789/4885
US-20050124656-A1 Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases(ptps) PTPRS, PTPA, PTPMT1 HRH3 3629/4885TAAR1 1657/4885LOXL2 2570/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.