Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.43 |
| ▸ | PTGES | O14684 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 4/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1851799 | 0.84 | ACACB (0.44) | ALOX5PTGESPPARGPLA2G4BACACB | |
| SCHEMBL1856893 | 0.82 | ALOX5 (0.42) | ALOX5PTGESPPARGPLA2G4BACACB | |
| SCHEMBL5045341 | 0.79 | PPARA (0.44) | PPARGPLA2G4BACACBS1PR4S1PR1 | |
| SCHEMBL1851802 | 0.77 | PTGES (0.44) | ALOX5PTGESPPARGACACBS1PR1 | |
| SCHEMBL1853816 | 0.76 | PTGES (0.43) | ALOX5PTGESPPARGPLA2G4BACACB | |
| SCHEMBL5039929 | 0.74 | S1PR2 (0.49) | ACACBS1PR1S1PR3FAAH | |
| SCHEMBL6023332 | 0.74 | NR5A1 (0.42) | PLA2G4BACACBS1PR1FAAHTP53 | |
| SCHEMBL28423723 | 0.73 | NR5A1 (0.56) | PLA2G4BTP53TSHRPPARA | |
| SCHEMBL1855304 | 0.73 | ACACB (0.42) | PTGESACACBFAAH | |
| SCHEMBL1852713 | 0.73 | ACACB (0.51) | ACACBFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-B1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | MERCK SERONO SA (CH) | 2011-05-25 | — | — | EP | disclosed |