Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 10/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1856893 | 0.90 | ALOX5 (0.42) | ACACBMAOBPTGESALOX5PPARG | |
| SCHEMBL1851797 | 0.84 | ALOX5 (0.43) | ACACBPTGESALOX5PPARGFAAH | |
| SCHEMBL1851802 | 0.75 | PTGES (0.44) | ACACBPTGESALOX5PPARGMEN1 | |
| SCHEMBL5045341 | 0.75 | PPARA (0.44) | ACACBPPARGPLA2G4B | |
| SCHEMBL6023332 | 0.74 | NR5A1 (0.42) | ACACBFAAHPLA2G4B | |
| SCHEMBL5039929 | 0.74 | S1PR2 (0.49) | ACACBFAAH | |
| SCHEMBL1853816 | 0.74 | PTGES (0.43) | ACACBPTGESALOX5PPARGPLA2G4B | |
| SCHEMBL28423723 | 0.73 | NR5A1 (0.56) | PLA2G4BCYP1A1CYP1B1 | |
| SCHEMBL1855304 | 0.73 | ACACB (0.42) | ACACBPTGESFAAH | |
| SCHEMBL1855943 | 0.72 | ACACB (0.42) | ACACBPTGESFAAHPLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-B1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | MERCK SERONO SA (CH) | 2011-05-25 | — | — | EP | disclosed |