⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29619760 | 1.00 | — | — | |
| SCHEMBL28202640 | 0.97 | CA3 (0.59) | — | |
| SCHEMBL29521801 | 0.97 | CA3 (0.59) | — | |
| SCHEMBL28141559 | 0.90 | ESR2 (0.54) | — | |
| SCHEMBL28953264 | 0.88 | CA3 (0.56) | — | |
| SCHEMBL28141519 | 0.84 | HSD17B1 (0.58) | — | |
| Parachlorophenol SCHEMBL28140781 | 0.82 | CA3 (0.50) | — | |
| P-Cresol SCHEMBL28161633 | 0.82 | ACHE (0.52) | — | |
| 2-Chlorophenol SCHEMBL28141531 | 0.81 | ALDH1A1 (0.58) | — | |
| SCHEMBL9221458 | 0.79 | HSD17B1 (0.64) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3122 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230310454-A1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | RIGEL PHARMACEUTICALS, INC. | 2023-10-05 | — | — | US | claimed |
| CN-116789201-A | Method for catalytic degradation of pollutants | 南京大学 | 2023-09-22 | — | — | CN | claimed |
| CN-116495865-A | Method for degrading phenolic compounds in water body | 南京大学 | 2023-07-28 | — | — | CN | claimed |
| US-11564930-B2 | RIP1 inhibitory compounds and methods for making and using the same | RIGEL PHARMACEUTICALS, INC. (US) | 2023-01-31 | — | — | US | claimed |
| CN-115554814-A | Method for capturing carbon dioxide by using ternary solvent system based on super-strong alkali ionic liquid | 中国地质大学（北京） | 2023-01-03 | — | — | CN | claimed |
| CN-115279763-A | RIP1 inhibiting compounds and methods of making and using the same | 里格尔药品股份有限公司 | 2022-11-01 | — | — | CN | claimed |
| EP-4025568-A1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | Rigel Pharmaceuticals, Inc. (US) | 2022-07-13 | — | — | EP | claimed |
| EP-4025574-A1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | Rigel Pharmaceuticals, Inc. (US) | 2022-07-13 | — | — | EP | claimed |
| EP-4025575-A1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | Rigel Pharmaceuticals, Inc. (US) | 2022-07-13 | — | — | EP | claimed |
| CN-114728918-A | RIP1 inhibiting compounds and methods of making and using the same | 里格尔药品股份有限公司 | 2022-07-08 | — | — | CN | claimed |
| EP-0973767-A1 | INDAZOLES OF CYCLIC UREAS USEFUL AS HIV PROTEASE INHIBITORS | Dupont Pharmaceuticals Company (US) | 2000-01-26 | — | — | EP | claimed |
| US-5985867-A | TREATING HIV INFECTION | DUPONT PHARMACEUTICALS COMPANY (US) | 1999-11-16 | — | — | US | claimed |
| WO-1998043969-A1 | INDAZOLES OF CYCLIC UREAS USEFUL AS HIV PROTEASE INHIBITORS | DUPONT PHARMACEUTICALS COMPANY (US) | 1998-10-08 | — | — | WO | claimed |
| WO-1996012723-A1 | PROCESS FOR PREPARING ALKYLSILYL OR ARYLSILYL ETHERS | FMC CORPORATION (US) | 1996-05-02 | — | — | WO | claimed |
| US-5493044-A | Process for preparing alkylsilyl or arylsilyl ethers | FMC CORPORATION (US) | 1996-02-20 | — | — | US | claimed |
| EP-0136063-B1 | TRIAZOLE ANTIFUNGAL AGENTS | Pfizer Limited (GB) | 1990-02-07 | — | — | EP | claimed |
| US-4827000-A | REACTION OF FLUOROPHTHALIC ANHYDRIDE WITH A PHENOL | OCCIDENTAL CHEMICAL CORPORATION (US) | 1989-05-02 | — | — | US | claimed |
| EP-0308863-A2 | Process for the preparation of phenoxy phthalic anhydrides | OCCIDENTAL CHEMICAL CORPORATION (US) | 1989-03-29 | — | — | EP | claimed |
| US-4638007-A | 1-(3-SUBSTITUTED)-2-HYDROXY-2-PERFLUORO ALKYL PROPYL TRIAZOLE | PFIZER INC. (US) | 1987-01-20 | — | — | US | claimed |
| EP-0136063-A2 | Triazole antifungal agents | Pfizer Limited (GB) | 1985-04-03 | — | — | EP | claimed |