Sugi Predict

Sugi Predict / Compounds / SCHEMBL18523600

SCHEMBL18523600

SCHEMBL18523600

CCCCCc1ccc(-c2cc3ccc(OCCC/C=C/CCCO)cc3oc2=O)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAOB P27338 2/20 0.50
▸ NPC1 O15118 5/20 0.48
▸ RAB9A P51151 5/20 0.48
▸ MAOA P21397 1/20 0.48
▸ KDM4E B2RXH2 2/20 0.47
▸ ALDH1A1 P00352 2/20 0.47
▸ GLA P06280 2/20 0.47
▸ GAA P10253 2/20 0.47
▸ HPGD P15428 2/20 0.47
▸ SMN1; SMN2 Q16637 2/20 0.47
▸ RECQL P46063 1/20 0.47
▸ HSD17B10 Q99714 1/20 0.47
▸ PTPN7 P35236 1/20 0.47
▸ TP53 P04637 1/20 0.47
▸ ACHE P22303 6/20 0.46
▸ BCHE P06276 3/20 0.46
▸ POLB P06746 1/20 0.46
▸ MAPT P10636 1/20 0.46
▸ PKM P14618 1/20 0.46
▸ MAPK1 P28482 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18523586 1.00 MAOB (0.50) MAOBNPC1RAB9AMAOAKDM4E
SCHEMBL21524311 0.99 MAOB (0.49) MAOBNPC1RAB9AMAOAKDM4E
SCHEMBL18583503 0.94 MAOB (0.52) MAOBNPC1RAB9AMAOAKDM4E
SCHEMBL23713497 0.91 NPC1 (0.48) MAOBNPC1RAB9AMAOAKDM4E
SCHEMBL21116178 0.91 NPC1 (0.50) MAOBNPC1RAB9AMAOAKDM4E
SCHEMBL18523585 0.91 MAOB (0.48) MAOBNPC1RAB9AMAOAKDM4E
SCHEMBL18523584 0.91 MAOB (0.48) MAOBNPC1RAB9AMAOAKDM4E
SCHEMBL18523589 0.90 MAOB (0.56) MAOBNPC1RAB9AMAOAKDM4E
SCHEMBL18535521 0.89 THRB (0.47) MAOBNPC1RAB9AMAOAKDM4E
SCHEMBL24046293 0.88 NPC1 (0.45) MAOBNPC1RAB9AMAOAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11958819-B2 Compounds for optically active devices Johnson & Johnson Surgical Vision, Inc. (US) 2024-04-16 — — US disclosed
CN-107922369-B Compounds for optically active devices 默克专利股份有限公司 2021-12-07 — — CN disclosed
US-20210363122-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES MERCK PATENT GMBH (DE) 2021-11-25 — — US disclosed
US-20210363122-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES MERCK PATENT GMBH (DE) 2021-11-25 — — US disclosed
US-11111226-B2 Hydrophilic compounds for optically active devices MERCK PATENT GMBH (DE) 2021-09-07 — — US disclosed
US-11078177-B2 Compounds for optically active devices MERCK PATENT GMBH (DE) 2021-08-03 — — US disclosed
US-11078177-B2 Compounds for optically active devices MERCK PATENT GMBH (DE) 2021-08-03 — — US disclosed
EP-3337794-B1 HYDROPHILIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES MERCK PATENT GMBH (DE) 2021-07-21 — — EP disclosed
US-20200262805-A1 HYDROPHILIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES MERCK PATENT GMBH (DE) 2020-08-20 — — US disclosed
US-10723713-B2 Hydrophilic compounds for optically active devices MERCK PATENT GMBH (DE) 2020-07-28 — — US disclosed
US-10457658-B2 Compounds for optically active devices MERCK PATENT GMBH (DE) 2019-10-29 — — US disclosed
US-10457658-B2 Compounds for optically active devices MERCK PATENT GMBH (DE) 2019-10-29 — — US disclosed
US-20180237409-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES MERCK PATENT GMBH (DE) 2018-08-23 — — US disclosed
EP-3337792-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES Merck Patent GmbH (DE) 2018-06-27 — — EP disclosed
WO-2017032442-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES MERCK PATENT GMBH (DE) 2017-03-02 — — WO disclosed
WO-2017032444-A1 HYDROPHILIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES MERCK PATENT GMBH (DE) 2017-03-02 — — WO disclosed
WO-2017032442-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES MERCK PATENT GMBH (DE) 2017-03-02 — — WO disclosed
EP-3133065-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES Merck Patent GmbH (DE) 2017-02-22 — — EP disclosed
EP-3133066-A1 HYDROPHILIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES Merck Patent GmbH (DE) 2017-02-22 — — EP disclosed
EP-3133065-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES Merck Patent GmbH (DE) 2017-02-22 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210363122-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES PDE6C, ALDH1A2, PDE6A MAOB 212/4885NPC1 2482/4885RAB9A 930/4885
US-10457658-B2 Compounds for optically active devices PDE6C, ALDH1A2, PDE6A MAOB 212/4885NPC1 2482/4885RAB9A 930/4885
US-11958819-B2 Compounds for optically active devices PDE6C, ALDH1A2, PDE6A MAOB 2878/4885NPC1 4820/4885RAB9A 4486/4885
US-11111226-B2 Hydrophilic compounds for optically active devices AQP1, AQP3, AQP4 MAOB 2614/4885NPC1 2773/4885RAB9A 2065/4885
US-20200262805-A1 HYDROPHILIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES AQP1, AQP3, AQP4 MAOB 2614/4885NPC1 2773/4885RAB9A 2065/4885
US-10723713-B2 Hydrophilic compounds for optically active devices AQP1, AQP3, AQP4 MAOB 2614/4885NPC1 2773/4885RAB9A 2065/4885
US-20180237409-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES PDE6C, ALDH1A2, PDE6A MAOB 212/4885NPC1 2482/4885RAB9A 930/4885
US-11078177-B2 Compounds for optically active devices PDE6C, ALDH1A2, PDE6A MAOB 212/4885NPC1 2482/4885RAB9A 930/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.