Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 1/20 | 0.67 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.67 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.57 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | PI4KA | P42356 | 1/20 | 0.48 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.48 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL783783 | 0.80 | NAE1 (1.00) | NAE1UBA3DAPK1SCN9AHPGD | |
| SCHEMBL17115735 | 0.73 | DAPK1 (1.00) | DAPK1SCN9AHPGDADORA2API4KA | |
| 9-Benzyl-6-Methoxy-9H-Purine SCHEMBL28939425 | 0.73 | HPGD (0.77) | DAPK1SCN9AHPGDADORA2API4KA | |
| SCHEMBL805389 | 0.73 | NAE1 (0.73) | NAE1UBA3DAPK1SCN9AHPGD | |
| SCHEMBL2980291 | 0.70 | ADORA2A (0.70) | DAPK1HPGDADORA2API4KAPI4K2B | |
| SCHEMBL30984022 | 0.70 | ADORA2A (0.70) | DAPK1HPGDADORA2API4KAPI4K2B | |
| SCHEMBL30983894 | 0.70 | DAPK1 (0.65) | NAE1UBA3DAPK1SCN9AHPGD | |
| SCHEMBL2979897 | 0.69 | ADORA2A (0.68) | DAPK1HPGDADORA2API4KAPI4K2B | |
| SCHEMBL30983811 | 0.68 | DAPK1 (0.62) | NAE1UBA3DAPK1SCN9AHPGD | |
| SCHEMBL28950094 | 0.67 | ADORA2A (0.65) | DAPK1HPGDADORA2API4KAPI4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170050935-A1 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF E1 ACTIVATING ENZYMES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050935-A1 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF E1 ACTIVATING ENZYMES | RCE1, ECE1, UBE2E1 | NAE1 24/4885UBA3 6/4885DAPK1 2092/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.