Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAPK1 | P53355 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | PI4KA | P42356 | 1/20 | 0.53 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.53 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.53 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NAE1 | Q13564 | 1/20 | 0.45 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31269114 | 0.98 | DAPK1 (0.60) | DAPK1HPGDADORA2API4KAPI4K2B | |
| SCHEMBL30983894 | 0.95 | DAPK1 (0.65) | DAPK1HPGDADORA2API4KAPI4K2B | |
| SCHEMBL30983919 | 0.81 | DAPK1 (0.47) | DAPK1HPGDADORA2API4KAPI4K2B | |
| 9-Benzyl-6-Methoxy-9H-Purine SCHEMBL28939425 | 0.80 | HPGD (0.77) | DAPK1HPGDADORA2API4KAPI4K2B | |
| SCHEMBL30984101 | 0.79 | ADORA2A (0.56) | ADORA2A | |
| SCHEMBL30984102 | 0.79 | ADORA2A (0.56) | ADORA2A | |
| Lithium SCHEMBL30983994 | 0.78 | ADORA2A (0.55) | ADORA2A | |
| SCHEMBL17115735 | 0.77 | DAPK1 (1.00) | DAPK1HPGDADORA2API4KAPI4K2B | |
| SCHEMBL30984045 | 0.77 | DAPK1 (0.43) | DAPK1HPGDPDE4APDE4BPDE4C | |
| SCHEMBL30983852 | 0.74 | MEN1 (0.42) | DAPK1HPGDHRH4SCN9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4689155-A1 | USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS | Astrazeneca AB (SE) | 2026-02-11 | — | — | EP | disclosed |
| EP-4630410-A1 | POLQ INHIBITORS | Astrazeneca AB (SE) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024201368-A1 | USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS | ASTRAZENECA AB (SE) | 2024-10-03 | — | — | WO | disclosed |
| WO-2024121753-A1 | POLQ INHIBITORS | ASTRAZENECA AB (SE) | 2024-06-13 | — | — | WO | disclosed |