SCHEMBL1852745

SCHEMBL1852745

c1ccc(NC2=NCCO2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CFB P00751 1/20 0.49
ADRA2A P08913 11/20 0.46
ADRA2B P18089 11/20 0.46
ADRA2C P18825 11/20 0.46
TAAR1 Q96RJ0 1/20 0.46
POLB P06746 1/20 0.43
KCNN4 O15554 1/20 0.43
HSD17B10 Q99714 2/20 0.42
ADRA1A P35348 4/20 0.42
ALDH1A1 P00352 2/20 0.41
TSHR P16473 2/20 0.41
ALOX15 P16050 1/20 0.41
ALOX12 P18054 1/20 0.41
PTGS1 P23219 1/20 0.41
SLC6A2 P23975 1/20 0.41
MAPK1 P28482 1/20 0.41
PTGS2 P35354 1/20 0.41
HTR2B P41595 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11122793 0.89 ADRA2A (0.46) CFBADRA2AADRA2BADRA2CTAAR1
SCHEMBL4266232 0.79 HPGD (0.55) CFBTAAR1HTR3A
SCHEMBL7629026 0.78 ADRA2A (0.50) CFBADRA2AADRA2BADRA2CTAAR1
SCHEMBL6690990 0.77 PTGIR (0.43) CFBADRA2AADRA2BADRA2CTAAR1
SCHEMBL9558516 0.77 TAAR1 (0.45) CFBADRA2AADRA2BADRA2CTAAR1
SCHEMBL7047648 0.74 TAAR1 (0.56) CFBADRA2AADRA2BADRA2CTAAR1
SCHEMBL9559073 0.73 ADRA2A (0.47) CFBADRA2AADRA2BADRA2CTAAR1
SCHEMBL29920861 0.73 ADRA2A (0.59) ADRA2AADRA2BADRA2CPOLBHSD17B10
SCHEMBL19565793 0.72 TAAR1 (0.47) CFBADRA2AADRA2BADRA2CTAAR1
SCHEMBL2754359 0.72 HSD17B10 (0.51) CFBADRA2AADRA2BADRA2CTAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115322231-B Oxazolinyl N, N-bidentate iron complex, preparation method and application 大连理工大学 2024-01-26 CN claimed
CN-115322231-A Oxazoline-based N, N-bidentate iron complex, preparation method and application 大连理工大学 2022-11-11 CN claimed
CN-108623731-B Aniline-oxazoline rare earth metal catalyst, preparation method and application 大连理工大学 2020-06-12 CN claimed
CN-108623731-A - oxazoline rare-earth metal catalyst of aniline, preparation method and application 大连理工大学 2018-10-09 CN claimed
EP-2035436-B1 FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS UCB PHARMA SA (BE) 2011-05-25 EP claimed
CN-115322231-B Oxazolinyl N, N-bidentate iron complex, preparation method and application 大连理工大学 2024-01-26 CN disclosed
CN-115322231-A Oxazoline-based N, N-bidentate iron complex, preparation method and application 大连理工大学 2022-11-11 CN disclosed
CN-115322231-A Oxazoline-based N, N-bidentate iron complex, preparation method and application 大连理工大学 2022-11-11 CN disclosed
CN-108586372-B Synthesis method of 2-aryl oxazoline amide compound 商丘师范学院 2021-06-08 CN disclosed
CN-108623731-B Aniline-oxazoline rare earth metal catalyst, preparation method and application 大连理工大学 2020-06-12 CN disclosed
CN-108623731-B Aniline-oxazoline rare earth metal catalyst, preparation method and application 大连理工大学 2020-06-12 CN disclosed
CN-108623731-B Aniline-oxazoline rare earth metal catalyst, preparation method and application 大连理工大学 2020-06-12 CN disclosed
US-5338828-A Mesogenic cyclic imino ether-containing compositions and polymerization products thereof THE DOW CHEMICAL COMPANY (US) 1994-08-16 US disclosed
US-5281675-A Liquid crystal polymers THE DOW CHEMICAL COMPANY (US) 1994-01-25 US disclosed
EP-0030350-B1 METHOD FOR REDUCING THE TERMINAL CARBOXYL GROUP CONTENT OF A SATURATED POLYESTER, A SATURATED POLYESTER HAVING A REDUCED TERMINAL CARBOXYL GROUP CONTENT, AND A MOLDED ARTICLE COMPOSED OF SUCH A SATURATED POLYESTER TEIJIN LIMITED (JP) 1984-10-10 EP disclosed
US-4351936-A COMPRISING ENDCAPPING WITH AN OXAZOLINE OR OXAZINE TEIJIN LIMITED (JP) 1982-09-28 US disclosed
EP-0030350-A1 Method for reducing the terminal carboxyl group content of a saturated polyester, a saturated polyester having a reduced terminal carboxyl group content, and a molded article composed of such a saturated polyester TEIJIN LIMITED (JP) 1981-06-17 EP disclosed
US-4176120-A HYPOTENSIVE AGENTS SCHERING CORPORATION (US) 1979-11-27 US disclosed
US-4159335-A HYPOTENSIVE AGENT SCHERING CORPORATION (US) 1979-06-26 US disclosed
US-4081547-A PARA-POLYFLUOROISOPROPYL-ANILINO-2-OXAZOLINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHOD OF TREATING HYPERTENSION SCHERING CORPORATION (US) 1978-03-28 US disclosed